Q0UPL5

PR
Gene name
PAN2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KEGG Pathway
pno:SNOG_06299
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

370-475 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0UPL5

Entry ID Method Resolution Chain Position Source
AF-Q0UPL5-F1 Predicted AlphaFoldDB

No variants for Q0UPL5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0UPL5

No associated diseases with Q0UPL5

3 regional properties for Q0UPL5

Type Name Position InterPro Accession
domain Exonuclease, RNase T/DNA polymerase III 878 - 1062 IPR013520
domain PAN2, UCH domain 489 - 804 IPR028881
domain Ubiquitin specific protease domain 489 - 830 IPR028889

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEADWNELVT AQLSPPGSHP PAVPISTFAF DTTQELLWTG NNQGRVTSLY GPSLERYTSY
70 80 90 100 110 120
RGHATSDGPV KQFLFTDKGV LSISRQSVHY SHRRGLTQWH LTSPDFKDLK CMNFTSKGTR
130 140 150 160 170 180
EILIAGCQEQ MFKVDVEKGI VVDTLPVDAQ YTIMKRAGQY LCAATKTGGI HILDSNSLSV
190 200 210 220 230 240
IKVFEGHTGS ISDMDAKGDF LATCGWSPRQ QYAYMLDPFT NVFSLKTLKQ LAPVPFHTGA
250 260 270 280 290 300
AFVRMHPRMS TTAIIASQNG QMQVIDLMNP DSANLRQLNL YDSYLAGFEM APSGEAFALA
310 320 330 340 350 360
DSNSNVHLWG SPAKVHFPEY SNPTEFADHV IPPASMDWSL DTPLNTIGMP YYKETLLSGW
370 380 390 400 410 420
PSHMVFEVGA PPPKIDGAIL SNMTRTDMGF FAKNPRTKRR NQIEVTRQTD RSSDSLTPPK
430 440 450 460 470 480
FLSEKSRASL SLSEANAKAV ETMETLTDLH LDDVTRKDVP AMYGNVEIKY SKFGVDDFDF
490 500 510 520 530 540
AYYNQTPFSG LETHITNSYA NSLLQLFRFT PLIRNLALQH TASPCLFESC LLCELGFLID
550 560 570 580 590 600
MLEKAAGLNC QASNFLKTFS GLSNAVSLNL LEEFAPNVAL TSMIQNLNRF LLDKISEEFR
610 620 630 640 650 660
QMLPSHGGTS LMDQVLETQA RASMRCAQCA NETIRGGKNF VNELVYPAKH VMKNTRIPRP
670 680 690 700 710 720
TFSQILKASV ERQDQTRGWC TKCNRYQQMV QRKTIQSVPG VLMLNAAIQT HEAKLLWSIP
730 740 750 760 770 780
NWLPHEIGII VDQGQFYCFE GQDLKLHLQR GVFDIMVYEL VGVVADINSG EHQKPHLVAT
790 800 810 820 830 840
INTGPSSREP DAEDKWHLFN DFLVRPIPRE EALRFEPSWK LPSVLTFQTK SARNKIDDSW
850 860 870 880 890 900
KENLDTSILY RWWSSNPTPP DDKFKLLQVS TEAPRPGYPV AIDAEFIRLQ AEEIEMKADG
910 920 930 940 950 960
TRQTIRPDRK GLARVSVCRG EGEHAGLPFI DDYIAVTEQV VDYLTEWSGI SPGDLNRETS
970 980 990 1000 1010 1020
PHAPVSLKHA YKKLWLLLNL GCVFVGHSLA NDFRTINIHV PRSQVVDTSN LFFLPDFKRK
1030 1040 1050 1060 1070 1080
LNLKFLAWCV LKEQIQQDTH DSIEDATTAL KLWRKYEEFV DAGVLEPMLN DIYATGSQVK
1090 1100 1110 1120
FKAPGSGNRN SMPAGMTATG AGRDTPEPMT TPKKGGAFGG VGFRSPMRR