Q0UNA9

PR
Gene name
SEC13 (SNOG_06755)
Protein name
Protein transport protein SEC13
Names
Species
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KEGG Pathway
pno:SNOG_06755
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

130-203 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0UNA9

Entry ID Method Resolution Chain Position Source
AF-Q0UNA9-F1 Predicted AlphaFoldDB

No variants for Q0UNA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0UNA9

No associated diseases with Q0UNA9

9 regional properties for Q0UNA9

Type Name Position InterPro Accession
repeat WD40 repeat 6 - 44 IPR001680-1
repeat WD40 repeat 49 - 90 IPR001680-2
repeat WD40 repeat 95 - 136 IPR001680-3
repeat WD40 repeat 140 - 195 IPR001680-4
repeat WD40 repeat 202 - 244 IPR001680-5
repeat WD40 repeat 249 - 287 IPR001680-6
repeat G-protein beta WD-40 repeat 77 - 91 IPR020472-1
repeat G-protein beta WD-40 repeat 182 - 196 IPR020472-2
repeat G-protein beta WD-40 repeat 231 - 245 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Nucleus, nuclear pore complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
GATOR2 complex A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.
nuclear pore outer ring A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

12 GO annotations of biological process

Name Definition
COPII-coated vesicle budding The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear pore localization Any process in which nuclear pores are transported to, or maintained in, a specific location.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of ER to Golgi vesicle-mediated transport Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of protein exit from endoplasmic reticulum Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.
positive regulation of TOR signaling Any process that activates or increases the frequency, rate or extent of TOR signaling.
positive regulation of TORC1 signaling Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
protein exit from endoplasmic reticulum The directed movement of proteins from the endoplasmic reticulum.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADNGQNVDL LSIEANEVQH DAVLDYYGRR LATCSSDKTI KIFEVEGDKH TLVETLRGHE
70 80 90 100 110 120
GPVWCVAWAH PKYGNILASS SYDGKVIIWR EQSSTWQKIY EVALHTASVN IVAWAPHEVG
130 140 150 160 170 180
CLLACASSDG NVSVLEFKDN AWSHVIFQAC GSGVNSVSWA PAVAPGQVVS ASGNQAGAAR
190 200 210 220 230 240
RFVTGGSDCQ VKLWDFSAET GSWQSTQILT GHTDWVRDVA WSPTVLSKSY IASASQDKTV
250 260 270 280 290 300
RIWTSSDLRD WKSTVLNVDA VAWRVSWSLS GNVLAVSTGD NRVSLWKERL SGGWECVKTI
EE