Q0UHC4

PR
Gene name
GUA1 (SNOG_08840)
Protein name
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthetase, Glutamine amidotransferase
Species
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KEGG Pathway
pno:SNOG_08840
EC number
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

303-373 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0UHC4

Entry ID Method Resolution Chain Position Source
AF-Q0UHC4-F1 Predicted AlphaFoldDB

No variants for Q0UHC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0UHC4

No associated diseases with Q0UHC4

5 regional properties for Q0UHC4

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 217 - 541 IPR001674
domain GMP synthase, glutamine amidotransferase 18 - 209 IPR004739
domain Glutamine amidotransferase 20 - 205 IPR017926
domain NAD/GMP synthase 231 - 302 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 213 - 416 IPR025777

Functions

Description
EC Number 6.3.5.2 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.

2 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATDGSDPIP PHKTFDTILV LDFGSQYTHL ITRRLRELNV YSEMLPCNTK LADLPFTPKG
70 80 90 100 110 120
IILSGGPYSV YEEGAPHVDH AVFDLGVPIL GICYGLQEMA WHFGKNAGVA AGEKREYGHA
130 140 150 160 170 180
NLKVESHGGH MDELFKDVGN ELEVWMSHGD KLSNMPENFT TVATTTNAPF AGIAHKEKKY
190 200 210 220 230 240
YGIQFHPEVT HTKMGKTVLK NFAVDICQST TDWTMGKFVD QEITRIRKLV GEKGQVIGAV
250 260 270 280 290 300
SGGVDSTVAA KLMKEAIGDR FHAVMVDNGV LRLNEAKQVK ETLEKGLGIN LTVIDASDMF
310 320 330 340 350 360
LDRLKGITDN PEQKRKVIGN TFIEIFQEKA KEIAAAAKNS SNAGEIEWLL QGTLYPDVIE
370 380 390 400 410 420
SLSFKGPSQT IKTHHNVGGL PANMNLKLIE PLRELFKDEV RALGVELGIP EDLVWRHPFP
430 440 450 460 470 480
GPGIAIRILG EVTREQVRIA READYIFIEE IKAAGLYRNI SQAFAALLPV KAVGVMGDKR
490 500 510 520 530 540
VHDQVIALRA VETTDFMTAD WYPFDGEFLK RVSRRIVNEV NGVCRVVYDI TSKPPGTIEM
E