Q0TWF4

PR
Gene name
ATG22-1 (SNOG_16086/SNOG_16087)
Protein name
Autophagy-related protein 22-1
Names
Species
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KEGG Pathway
pno:SNOG_16087
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0TWF4

Entry ID Method Resolution Chain Position Source
AF-Q0TWF4-F1 Predicted AlphaFoldDB

No variants for Q0TWF4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0TWF4

1 associated diseases with Q0TWF4

[MIM: 601238]: Cerebellar ataxia, cayman type (ATCAY)

Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. {ECO:0000269|PubMed:14556008}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. {ECO:0000269|PubMed:14556008}. Note=The disease is caused by variants affecting the gene represented in this entry.

1 regional properties for Q0TWF4

Type Name Position InterPro Accession
domain CRAL-TRIO lipid binding domain 171 - 328 IPR001251

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
  • Vacuole and punctate structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of fungal-type vacuolar membrane The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
amino acid transmembrane export from vacuole The directed movement of amino acids out of the vacuole, across the vacuolar membrane.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLNSEEDEA ELVQLQPRYN GEDTSATTNR ELNGWYAYPI AAEVFAVVAV GAFLPVILEQ
70 80 90 100 110 120
LARENGYFFS DSTKSCVDHG GSRRMRAEDG LKGSEQCMIK ILNSTISTSS FAMYTFSAAV
130 140 150 160 170 180
IVQAVTLVCF SSFADHGPYR KKMLMAFAYT GSVASALFIF ISPTVYFLAP ILVIVGVTSL
190 200 210 220 230 240
GCSFVLLNAF LPLLVANHAN NTGAKFATAD SSSDFELEAL NPNTQCGQSH ARSAHMSSRG
250 260 270 280 290 300
VGYGYMAAVF VQVISILILW LFSKTAIQKR HPSLPIRVIL LLVGMWWAAL TTPTLLWLRP
310 320 330 340 350 360
RPGPPLPSQE AKTLSAPTSR FRTFLFYTRF SLRSFWRTLL RAISLRQTLM FLISWFLLSD
370 380 390 400 410 420
AVATISGTAV LFARTELHMG TIAIALLSIT SIGSGIIGAF AWPRVQKRFS LQPKTILLCC
430 440 450 460 470 480
VAGMEMIPLY GLLGFIPLFK KLGFIGLQQP WEIYPVAVLH GIVMGGVSSY ARSVYAPLIP
490 500 510 520 530 540
EGSEAAFFAL YAVTDKGSSA FGPALVGWLV DHAGSIRPAF IFLAVLVVLP APLLWMLDVE
550 560
KGREDAKAMA DGEGRGRGTY ERVREE