Q0T335
Gene name |
thiM |
Protein name |
Hydroxyethylthiazole kinase |
Names |
4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase |
Species |
Shigella flexneri serotype 5b (strain 8401) |
KEGG Pathway |
sfv:SFV_2159 |
EC number |
2.7.1.50: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0T335
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0T335-F1 | Predicted | AlphaFoldDB |
No variants for Q0T335
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q0T335 | |||||
No associated diseases with Q0T335
No regional properties for Q0T335
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q0T335 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.50 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hydroxyethylthiazole kinase activity | Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQVDLLSSAQ | SAHALHLFHQ | HSPLVHCMTN | DVVQTFTANT | LLALGASPAM | VIETEEASQF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAIASALLIN | VGTLTQPRAQ | AMRAAVEQAK | SSQTRWTLDP | VAVGALDYRR | HFCHELLSFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PAAIRGNASE | IMALAGIANG | GRGVDTTDAA | ANAIPAAQTL | ARETGAIVVV | TGEVDYVTDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HRIIGIHGGD | PLMTKVVGTG | CALSAVVAAC | CALPGDTLEN | VASACHWMKQ | AGERAVARSE |
| 250 | 260 | ||||
| GPGSFVPHFL | DALWQLTQEV | QA |