Q0SV78

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Clostridium perfringens (strain SM101 / Type A)
KEGG Pathway
cpr:CPR_0645
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

238-327 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0SV78

Entry ID Method Resolution Chain Position Source
AF-Q0SV78-F1 Predicted AlphaFoldDB

No variants for Q0SV78

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0SV78

No associated diseases with Q0SV78

4 regional properties for Q0SV78

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 414 - 604 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 663 - 777 IPR013155
domain Methionyl/Leucyl tRNA synthetase 40 - 186 IPR015413
domain Leucyl-tRNA synthetase, editing domain 219 - 400 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGNYSTAIDK KWQDKWAESG LYKFDPNKEV EKLYVLEMFS YPSGSQLHAG HWFNYGPVDS
70 80 90 100 110 120
WARFKRMQGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST IKNIAKMEEQ LKAMGAMFNW
130 140 150 160 170 180
ENEVVTCSPE YYKWTQWLFL KLYEKGLAYR KKAPVNWCPS CQTVLANEQV VDGACERCST
190 200 210 220 230 240
EVTKKDLTQW FFKITDYADE LLDKLDGLDW PEKTVSMQKH WIGRSTGSQV NFKVKDSDLN
250 260 270 280 290 300
FDVFTTRVDT LCGVSYVVLA PENPLVDEIV SAEQKEAVEN YKEEAKKQSD IERQSISREK
310 320 330 340 350 360
TGVFTGAYAI HPLTGKEVPI WVGDYVLATY GTGAVMAVPA HDERDFAFAE KFNLPINRVI
370 380 390 400 410 420
EAKDGSETNL PFCEHGILVN SGEFDGLTTD EAKEKIVEKL ASMGLGEKKV NFRLRDWLVS
430 440 450 460 470 480
RQRYWGAPIP VVYCEECGIV PVPESQLPVE LPYDVEFAPD GKSPLAKSEA FVNTTCPHCG
490 500 510 520 530 540
KPAKRETDTL DTFVCSSWYY LRYPDNKNTE APFNPELINK MLPVDKYVGG PEHACMHLLY
550 560 570 580 590 600
ARFITKALRD MGYLNFDEPF TSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR
610 620 630 640 650 660
MYLMFGFAYT EGGAWSDDGI KSVNRFVERI ERIIDTAREA ISKGENNKTT MDKAEKELNY
670 680 690 700 710 720
WRHNTIKSVT DDTDKLQFNT AIARMMEFIN ALSKYTQEKE MNLDFLKDVV SDYLRLLAPF
730 740 750 760 770 780
APHFSEEQWN LLGNSYSIFN EAWPKFDPKA LVKDEVEIAI QVNGKIKNKI MVSSDLDEEG
790 800 810
IKAAALADEK IIASTEGKTV VKVIVIKGRL VNIVVK