AiPD: Autoinhibited Protein Database

Q0P651

Gene name	ABHD18
Protein name	Protein ABHD18
Names	Alpha/beta hydrolase domain-containing protein 18, Abhydrolase domain-containing protein 18
Species	Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

246-357 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

246-357 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q0P651

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0P651-F1	Predicted				AlphaFoldDB

308 variants for Q0P651

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs868867503 CA105663528	4	S>N		No	ClinGen Ensembl
CA105663529 rs759840611 CA358167912	4	S>R		No	ClinGen TOPMed gnomAD
rs1230078382 CA358167938	6	L>F		No	ClinGen gnomAD
CA358167970 rs1343618527	9	L>V		No	ClinGen TOPMed
rs758565519 CA3077645	11	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1051142 CA3077644 rs750671699	11	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA358168015 rs1228354813	13	L>P		No	ClinGen gnomAD
rs1390095513 CA358168019	14	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1266588013	15	L>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1190689359 CA358168093	20	I>V		No	ClinGen gnomAD
CA105663637 rs868522262	21	R>I		No	ClinGen Ensembl
TCGA novel	22	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755502727 CA358168134	23	W>*		No	ClinGen ExAC gnomAD
rs755502727 CA3077650	23	W>S		No	ClinGen ExAC gnomAD
rs1165529198 CA358168156	25	R>K		No	ClinGen gnomAD
CA3077651 rs370471176	26	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA358168183 rs1474978064	27	E>A		No	ClinGen TOPMed
CA358168179 rs1474978064	27	E>G		No	ClinGen TOPMed
CA358168175 rs1456327345	27	E>Q		No	ClinGen gnomAD
CA358168199 rs1162441342	28	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	28	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1389034663 CA358168235	31	R>K		No	ClinGen TOPMed gnomAD
CA358168948 rs1579191298	38	M>K		No	ClinGen Ensembl
rs1223113040 CA358168961	39	I>V		No	ClinGen TOPMed
rs1466226523 CA358168975	40	G>R		No	ClinGen gnomAD
rs1579191379 CA358169010 COSM1051146	42	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
rs868003753 CA105664749	42	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs776631224 CA3077661	43	E>G		No	ClinGen ExAC gnomAD
CA358169035 rs1376272596	44	R>G		No	ClinGen gnomAD
rs1453492467 CA358169072	46	Q>R		No	ClinGen TOPMed gnomAD
rs761613127 CA3077662	49	V>L		No	ClinGen ExAC gnomAD
CA3077663 CA358169141 rs201269910	51	S>R		No	ClinGen ExAC TOPMed gnomAD
rs763200871 CA3077665	52	D>E		No	ClinGen ExAC gnomAD
CA358169142 rs560511632	52	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3077664 rs560511632	52	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358169143 rs560511632	52	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs546570012 CA3077666	53	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs1359236427 CA358169170	56	H>R		No	ClinGen TOPMed
CA3077667 rs751695029	56	H>Y		No	ClinGen ExAC gnomAD
rs1211021315 CA358169175	57	I>V		No	ClinGen TOPMed gnomAD
rs971145762 CA105664834	58	D>V		No	ClinGen TOPMed
rs1286865615 CA358169519	60	I>V		No	ClinGen gnomAD
CA358169559 rs1236149576	65	D>V		No	ClinGen TOPMed
CA3077675 rs758185567	67	K>Q		No	ClinGen ExAC
TCGA novel	70	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358169606 rs1275435894	72	H>N		No	ClinGen gnomAD
CA358169610 rs1483997171	72	H>R		No	ClinGen gnomAD
rs1216948195 CA358169622	74	V>I		No	ClinGen TOPMed
CA358169637 rs1232113327	76	P>R		No	ClinGen gnomAD
rs996439290 CA105669224	76	P>S		No	ClinGen TOPMed
rs775951168 CA3077679	77	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	77	M>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199789137 CA3077681	78	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3077680 rs199789137	78	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3077682 rs773055898	79	H>Y		No	ClinGen ExAC gnomAD
CA358169660 rs1432219392	80	Y>H		No	ClinGen gnomAD
rs1168683411 CA358169693	83	D>G		No	ClinGen gnomAD
CA3077684 rs762721892	84	I>T		No	ClinGen ExAC TOPMed gnomAD
CA3077686 rs186826737	86	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186826737 CA358169729	86	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186826737 CA3077685	86	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358169750 rs1015238270	88	E>*		No	ClinGen gnomAD
CA105669291 rs1015238270	88	E>Q		No	ClinGen gnomAD
TCGA novel	89	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3077687 rs199862084	90	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077688 rs199862084	90	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077689 rs752689913	92	A>G		No	ClinGen ExAC gnomAD
rs765743526 CA3077714	93	R>S		No	ClinGen ExAC gnomAD
rs1354721536 CA358172627	98	V>L		No	ClinGen gnomAD
CA358172634 rs1289982574	99	P>H		No	ClinGen gnomAD
rs754725341 CA3077716	99	P>S		No	ClinGen ExAC gnomAD
CA358172638 rs1326650304	100	K>E		No	ClinGen gnomAD
rs780694361 CA3077717	103	N>Y		No	ClinGen ExAC gnomAD
CA358172674 rs1278736222	104	S>N		No	ClinGen gnomAD
rs1443598097 CA358172681	105	K>R		No	ClinGen gnomAD
rs867186579 CA105683100	106	Y>C		No	ClinGen gnomAD
rs1475159428 CA358172703	108	P>H		No	ClinGen gnomAD
CA358172705 rs1183436926	109	V>I		No	ClinGen gnomAD
CA358172707 rs1183436926	109	V>L		No	ClinGen gnomAD
rs1579336837 CA358172720	111	I>V		No	ClinGen Ensembl
rs952889212 CA105683124	116	T>A		No	ClinGen TOPMed
CA3077721 rs567962998	117	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA358172793 rs1302079040	120	H>R		No	ClinGen TOPMed gnomAD
TCGA novel	123	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358172821 rs574956758	124	R>*		No	ClinGen 1000Genomes TOPMed gnomAD
rs574956758 CA105683222	124	R>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA105683228 rs769642474	124	R>Q		No	ClinGen gnomAD
rs773100732 COSM1426980 CA3077745	125	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA358172825 COSM1426982 rs1186504338	125	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1195658337 CA358172848	129	A>T		No	ClinGen TOPMed gnomAD
rs748228526 CA358172855	130	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3077747 rs748228526	130	R>G		No	ClinGen ExAC TOPMed gnomAD
CA105683236 rs762996383	130	R>H		No	ClinGen TOPMed gnomAD
rs769855907 CA3077748	131	P>T		No	ClinGen ExAC TOPMed gnomAD
CA3077750 rs767446806	132	M>I		No	ClinGen ExAC TOPMed gnomAD
rs773598649 CA3077749	132	M>V		No	ClinGen ExAC gnomAD
CA105683254 rs942302192	136	A>S		No	ClinGen gnomAD
rs1422365325 CA358172899	137	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs766702105 CA3077751	137	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1038337058 CA105683257	138	M>R		No	ClinGen Ensembl
CA3077752 rs560711930	139	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA3077753 rs560711930	139	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA358172919 rs1392543667	140	S>F		No	ClinGen gnomAD
CA358172923 rs1458062993	141	L>S		No	ClinGen TOPMed
rs1161848380 CA358172929	142	L>S		No	ClinGen TOPMed
CA3077755 rs763721644	145	N>K		No	ClinGen ExAC gnomAD
rs1463604363 CA555019932	147	Y>*		No	ClinGen TOPMed gnomAD
rs1560895503 CA358172993	148	Y>C		No	ClinGen Ensembl
rs1185212348 CA358172997	149	G>S		No	ClinGen TOPMed
CA358173006 rs777886651	150	C>F		No	ClinGen gnomAD
CA358173008 rs777886651	150	C>Y		No	ClinGen gnomAD
CA358173011 rs1459724296	151	R>G		No	ClinGen gnomAD
rs1163930460 CA358173017	151	R>S		No	ClinGen gnomAD
rs1402130350 CA358173033	154	K>E		No	ClinGen gnomAD
CA358173052 rs1228116212	156	Q>R		No	ClinGen Ensembl
rs1294931929 CA358169212	158	R>M		No	ClinGen TOPMed
CA3077777 rs750162292	158	R>S		No	ClinGen ExAC TOPMed gnomAD
CA3077778 rs749921776	160	S>G		No	ClinGen ExAC gnomAD
CA3077780 rs762868585	162	K>E		No	ClinGen ExAC gnomAD
TCGA novel	163	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358169248 rs1234141242	163	N>K		No	ClinGen gnomAD
rs939047850 CA105685253	164	V>M		No	ClinGen TOPMed
CA3077783 rs199818126	166	D>H		No	ClinGen ExAC gnomAD
CA3077782 rs199818126	166	D>N		No	ClinGen ExAC gnomAD
CA3077785 rs752989934	167	L>H		No	ClinGen ExAC gnomAD
CA3077786 rs756328534	170	M>T		No	ClinGen ExAC gnomAD
rs1175240952 CA358169298	171	G>E		No	ClinGen gnomAD
rs777781413 CA3077788	172	G>E		No	ClinGen ExAC gnomAD
rs1433400427 CA358169316	174	L>P		No	ClinGen gnomAD
CA358169322 rs1177604696	175	V>A		No	ClinGen gnomAD
CA358169350 COSM1426984 rs1393459982	179	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1433425600 CA358169352	180	A>P		No	ClinGen gnomAD
rs1173516874 CA358169359	181	L>F		No	ClinGen gnomAD
rs1173516874 CA358169358	181	L>V		No	ClinGen gnomAD
TCGA novel	182	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3077791 rs779395033 CA358169385	184	W>C		No	ClinGen ExAC gnomAD
rs200066744 CA3077793	187	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1579392508 CA358169408	188	E>G		No	ClinGen Ensembl
CA3077794 rs775805089	188	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1233622070 CA358169417	189	G>V		No	ClinGen gnomAD
CA358169421 rs1476563489	190	Y>C		No	ClinGen gnomAD
CA3077795 rs761417024	191	G>S		No	ClinGen ExAC TOPMed gnomAD
rs772658667 CA3077797	194	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1488608831 CA358169464	197	G>R		No	ClinGen gnomAD
TCGA novel	199	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762540377 CA3077798	199	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA3077800 rs751579898	200	M>I		No	ClinGen ExAC gnomAD
CA3077799 rs765922969	200	M>V		No	ClinGen ExAC TOPMed gnomAD
rs200952665 CA358169508	203	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759499203 CA3077801	203	H>R		No	ClinGen ExAC TOPMed gnomAD
CA3077826 rs757444653	204	M>I		No	ClinGen ExAC TOPMed gnomAD
rs202204733 CA105686837	204	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077825 rs202204733	204	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs765337908 CA3077827	207	L>S		No	ClinGen ExAC TOPMed gnomAD
CA3077828 COSM203701 rs761660121	208	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA105686880 rs537069265 CA3077830	211	N>K		No	ClinGen ExAC gnomAD
rs1015969705 CA105686861	211	N>S		No	ClinGen TOPMed gnomAD
CA358169798 rs1378523088	212	W>C		No	ClinGen TOPMed
rs974862964 CA105686881	219	I>N		No	ClinGen TOPMed
CA358169854 rs1211235725	219	I>V		No	ClinGen gnomAD
CA358169865 rs1285788040	220	P>L		No	ClinGen gnomAD
CA105686886 rs868337589	223	S>F		No	ClinGen Ensembl
rs781364186 CA3077833	223	S>T		No	ClinGen ExAC gnomAD
rs1242107147 CA358169889	224	W>*		No	ClinGen gnomAD
rs770677812 CA3077835	226	T>A		No	ClinGen ExAC gnomAD
CA358169902 rs1193627047	226	T>K		No	ClinGen gnomAD
rs774061812 CA3077836 COSM319094	227	A>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1175774919 CA358169907	227	A>V		No	ClinGen TOPMed
TCGA novel	230	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745384841 CA3077838	230	V>F		No	ClinGen ExAC gnomAD
rs774107227 CA3077840	233	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3077842 rs760477366	233	T>K		No	ClinGen ExAC TOPMed gnomAD
rs760477366 CA3077841	233	T>M		No	ClinGen ExAC TOPMed gnomAD
rs774107227 CA3077839	233	T>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	235	D>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358171477 rs1219475798	236	S>T		No	ClinGen TOPMed
rs1165359481 CA358171532	240	G>*		No	ClinGen gnomAD
rs1027650461 CA105691426	240	G>V		No	ClinGen TOPMed
CA3077872 rs190125887	241	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358171545 rs1324661433	241	Q>R		No	ClinGen gnomAD
CA358171563 rs1383385636	242	E>D		No	ClinGen TOPMed gnomAD
CA358171553 rs1002275312	242	E>K		No	ClinGen TOPMed gnomAD
CA105691429 rs1002275312	242	E>Q		No	ClinGen TOPMed gnomAD
CA105691430 rs1020392118	243	F>I		No	ClinGen gnomAD
TCGA novel	243	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1325189557 CA358171588	246	H>Y		No	ClinGen gnomAD
CA3077873 rs767921744	249	S>G		No	ClinGen ExAC gnomAD
CA358171633 rs1294223803	249	S>R		No	ClinGen TOPMed gnomAD
rs753188106 CA3077874	250	S>G		No	ClinGen ExAC gnomAD
CA358171652 rs1231627834	251	A>S		No	ClinGen gnomAD
rs1231627834 CA358171650	251	A>T		No	ClinGen gnomAD
CA3077876 rs778233139	252	D>E		No	ClinGen ExAC
CA3077875 rs756577253	252	D>V		No	ClinGen ExAC TOPMed gnomAD
CA3077878 rs530111747	257	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3077877 rs530111747	257	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1259642716 CA358171725	258	N>Y		No	ClinGen gnomAD
rs779678124 CA3077879	260	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1188395781 CA358171782	263	T>A		No	ClinGen gnomAD
rs1560933730 CA358171787	263	T>I		No	ClinGen Ensembl
rs1162771243 CA358171797	264	L>F		No	ClinGen TOPMed
rs746484680 CA3077881	269	S>T		No	ClinGen ExAC TOPMed gnomAD
CA358171885 rs1369784076	272	V>I		No	ClinGen TOPMed
CA358171916 rs1163813206	274	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1034107618 CA105691465	278	A>V		No	ClinGen Ensembl
rs781116601 COSM1725934 CA3077885	279	D>Y	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3077886 rs748039911	280	C>Y		No	ClinGen ExAC gnomAD
rs769601961 CA3077887	281	H>R		No	ClinGen ExAC
CA358172023 rs1399875584	283	S>F		No	ClinGen gnomAD
CA358172039 rs1402514819	285	K>E		No	ClinGen gnomAD
CA358172063 rs1427368897	286	T>I		No	ClinGen TOPMed
rs1035534390 CA105691473	287	S>F		No	ClinGen TOPMed gnomAD
rs199644075 CA3077890	289	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1330582211 CA358172097	290	A>T		No	ClinGen gnomAD
rs58225850 CA3077891	290	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA105691508 rs1020843129	296	L>S		No	ClinGen TOPMed
CA358172163 rs753277762	297	L>*		No	ClinGen ExAC gnomAD
CA3077896 rs753277762	297	L>W		No	ClinGen ExAC gnomAD
CA3077897 rs761237962	299	D>V		No	ClinGen ExAC gnomAD
CA358172201 rs1305812471	302	K>N		No	ClinGen TOPMed
CA105691514 COSM3365490 rs1017084052	303	M>I	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
CA358172203 rs1280216286	303	M>V		No	ClinGen TOPMed
CA3077899 rs373013839	304	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077898 rs373013839	304	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077900 rs201787908	305	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077901 rs767049484	305	R>H	Variant assessed as Somatic; 4.641e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3077902 rs751161286	307	N>H		No	ClinGen ExAC gnomAD
rs35763794 CA3077903	307	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780634500 CA3077904	308	Q>H		No	ClinGen ExAC gnomAD
rs932329900 CA105691524	309	T>A		No	ClinGen TOPMed
CA3077905 rs748133822	311	S>*		No	ClinGen ExAC gnomAD
CA3077906 rs756016785	314	K>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA105691550 COSM3365492 rs375508834	314	K>R	kidney [Cosmic]	No	ClinGen cosmic curated ESP TOPMed
rs183677438 CA3077907	315	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3077908 rs749023538	316	G>R		No	ClinGen ExAC gnomAD
CA358172290 rs1304986347	317	Y>H		No	ClinGen gnomAD
CA358172297 rs1268713355	318	T>A		No	ClinGen TOPMed
rs141361679 CA3077909	320	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs141361679 CA3077910	320	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368434647 CA3077911	320	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282461049 CA358172317	321	N>S		No	ClinGen gnomAD
rs772325581 CA3077912	322	P>L		No	ClinGen ExAC gnomAD
rs1251618595 CA358172342	325	Y>H		No	ClinGen gnomAD
rs199917794 CA105691567	328	L>P		No	ClinGen 1000Genomes
rs761329589 CA3077914	330	K>E		No	ClinGen ExAC TOPMed gnomAD
CA3077915 rs764681255	331	E>V		No	ClinGen ExAC gnomAD
rs1454371026 CA358172391	332	Q>*		No	ClinGen gnomAD
CA3077916 rs777216469	333	S>G		No	ClinGen ExAC gnomAD
CA3077918 CA3077917 rs60505265	333	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751196852 CA3077919	336	S>G		No	ClinGen ExAC gnomAD
CA358172417 rs751196852	336	S>R		No	ClinGen ExAC gnomAD
rs754639860 CA3077920	337	L>P		No	ClinGen ExAC gnomAD
CA105691575 rs374051835	337	L>V		No	ClinGen ESP
CA3077922 rs752198419	338	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3077921 rs556836116	338	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1560935741 CA358172441 COSM159620	340	E>K	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA3077923 rs568611329	343	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1332587397 CA358172475	345	M>V		No	ClinGen TOPMed
CA3077926 rs749208645	349	M>T		No	ClinGen ExAC gnomAD
rs535438593 CA3077925	349	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA358172510 rs1324015956	350	D>N		No	ClinGen TOPMed
rs1218528047 CA358172521	351	E>A		No	ClinGen gnomAD
CA3077927 rs757023413	353	T>I		No	ClinGen ExAC gnomAD
CA3077928 rs778745875	354	H>P		No	ClinGen ExAC gnomAD
CA3077929 rs746113225	354	H>Q		No	ClinGen ExAC gnomAD
rs1390458947 CA358172541	354	H>Y		No	ClinGen TOPMed
TCGA novel	358	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3077946 rs778636734	361	P>R		No	ClinGen ExAC gnomAD
CA358173089 rs1467261271	363	D>Y		No	ClinGen TOPMed
CA358173095 rs1356139706	364	P>T		No	ClinGen TOPMed
rs1487099445 CA358173111	366	L>F		No	ClinGen gnomAD
CA105692462 rs371328232	367	I>T		No	ClinGen ESP TOPMed
rs866463998 CA105692468	368	I>T		No	ClinGen gnomAD
CA105692466 rs1043191062	368	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	369	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA105692471 rs185221344	370	V>F		No	ClinGen 1000Genomes ExAC gnomAD
rs185221344 CA3077950	370	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs976781449 CA105692474	371	Q>R		No	ClinGen TOPMed gnomAD
rs768881032 CA3077951	372	A>V		No	ClinGen ExAC gnomAD
CA3077952 rs559977339	373	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs748647095 CA3077953	374	E>D		No	ClinGen ExAC gnomAD
CA358173175 rs1428481661	376	A>V		No	ClinGen gnomAD
CA3077954 rs770330173	378	I>T		No	ClinGen ExAC TOPMed gnomAD
CA3077955 rs202120305	380	R>*		No	ClinGen ESP TOPMed gnomAD
CA358173197 rs367696956	380	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA3077957 rs367696956	380	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA358173205 rs1202262917	381	T>I		No	ClinGen Ensembl
rs763322382 CA3077958	382	G>V		No	ClinGen ExAC TOPMed gnomAD
CA358173218 rs1355205312 COSM3825171	384	R>*	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs771220150 CA3077959	384	R>Q		No	ClinGen ExAC gnomAD
rs1233914674 CA358173224	385	S>N		No	ClinGen TOPMed
rs775144265 CA3077960	387	Q>E		No	ClinGen ExAC gnomAD
rs934901153 CA105692513	390	W>C		No	ClinGen TOPMed gnomAD
CA358173267 rs1310773836	391	P>S		No	ClinGen TOPMed
rs1215040320 CA358173275	392	G>D		No	ClinGen gnomAD
CA3077961 rs760296163	393	C>*		No	ClinGen ExAC gnomAD
rs149965291 CA3077962	396	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs376691032 CA3077963	396	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1353183446 CA358173307	397	Y>C		No	ClinGen TOPMed
CA358173312 rs1378131893	398	L>V		No	ClinGen TOPMed gnomAD
CA3077964 rs761709628	399	E>K		No	ClinGen ExAC gnomAD
CA3077965 rs765230932 COSM447359 CA358173325	400	G>R	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD NCI-TCGA
CA3077967 rs758302240	405	A>V		No	ClinGen ExAC TOPMed gnomAD
CA358173365 rs1412595873	406	Y>H		No	ClinGen gnomAD
rs1447256881 CA358173373	407	L>V		No	ClinGen TOPMed
CA358173400 rs1158014749	410	Q>H		No	ClinGen gnomAD
CA358173399 rs1357211635	410	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA105692549 rs34975863	411	G>E		No	ClinGen Ensembl
rs1175347867 CA358173411	412	L>P		No	ClinGen TOPMed

No associated diseases with Q0P651

1 regional properties for Q0P651

Type	Name	Position	InterPro Accession
domain	Costars domain	304 - 380	IPR027817

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MGVSKLDILY	RRLLLTKLFI	RGWGRPEDLK	RLFEFRKMIG	NRERCQNLVS	SDYPVHIDKI
70	80	90	100	110	120
EEQSDCKILD	GHFVSPMAHY	VPDIMPIESV	IARFQFIVPK	EWNSKYRPVC	IHLAGTGDHH
130	140	150	160	170	180
YWRRRTLMAR	PMIKEARMAS	LLLENPYYGC	RKPKDQVRSS	LKNVSDLFVM	GGALVLESAA
190	200	210	220	230	240
LLHWLEREGY	GPLGMTGISM	GGHMASLAVS	NWPKPMPLIP	CLSWSTASGV	FTTTDSFKMG
250	260	270	280	290	300
QEFVKHFTSS	ADKLTNLNLV	SRTLNLDISN	QVVSQKPADC	HNSSKTSVSA	TSEGLLLQDT
310	320	330	340	350	360
SKMKRFNQTL	STNKSGYTSR	NPQSYHLLSK	EQSRNSLRKE	SLIFMKGVMD	ECTHVANFSV
370	380	390	400	410
PVDPSLIIVV	QAKEDAYIPR	TGVRSLQEIW	PGCEIRYLEG	GHISAYLFKQ	GLFR