Q0P5F9

PR
Gene name
ALDH8A1
Protein name
2-aminomuconic semialdehyde dehydrogenase
Names
Aldehyde dehydrogenase family 8 member A1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513537
EC number
1.2.1.32: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P5F9

Entry ID Method Resolution Chain Position Source
AF-Q0P5F9-F1 Predicted AlphaFoldDB

No variants for Q0P5F9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0P5F9

No associated diseases with Q0P5F9

1 regional properties for Q0P5F9

Type Name Position InterPro Accession
domain Anoctamin, dimerisation domain 108 - 332 IPR032394

Functions

Description
EC Number 1.2.1.32 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminomuconate-semialdehyde dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate.
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

3 GO annotations of biological process

Name Definition
L-kynurenine catabolic process The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).
retinal metabolic process The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05091 ALDH2 Aldehyde dehydrogenase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MAGRGGLLML ENFIGGKFLP CSSYLDSYDP STGEVYCHVP NSGKEEIEAA VEAARAAFPG
70 80 90 100 110 120
WSSRSPQERS QVLQRLADLL EQSLEELAQA ESKDQGKTIT LARTMDIPRA VHNFRFFASS
130 140 150 160 170 180
ILHHTSECTQ MDHLGCLHYT VRAPVGIAAL ISPWNLPLYL LTWKIAPAIA AGNTVIAKPS
190 200 210 220 230 240
ELTSVTAWMM CRLLEKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIM
250 260 270 280 290 300
QLSAPHCKKL SLELGGKNPA VIFEDANLAE CIPTTVRSSF ANQGEICLCT SRIFVQRSIY
310 320 330 340 350 360
SEFLKRFVEA ARMWKVGIPS DPSADMGALI SKAHLEKVRS YIKKARMEGA QILCGEGVDK
370 380 390 400 410 420
LNLPPRNQAG YFMLPTVITD VKDESCCMKE EIFGPVTCVV PFDSEEEVIQ RANNVKYGLA
430 440 450 460 470 480
ATVWSGNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGVGREGA KDSYEFFTEV
KTITVKH