Q0JMY1

SS
Gene name
PARP2-B (Os01g0351100, LOC_Os01g24920, B1051E10.53, P0463A02.23)
Protein name
Poly [ADP-ribose] polymerase 2-B
Names
PARP-2-B , EC 2.4.2.30 , NAD, + ADP-ribosyltransferase 2-B , ADPRT-2-B , Poly[ADP-ribose] synthase 2-B , Protein ADP-ribosyltransferase PARP2 , EC 2.4.2.-
Species
Caenorhabditis elegans
KEGG Pathway
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

Calcium-dependent, calmodulin-stimulated protein phosphatase calcineurin (CN) plays a role in the transduction of intracellular Ca2+-dependent signals. CN is a heterodimer composed of a catalytic subunit A (CNA) and an essential regulatory subunit B (CNB). <br>CNA contains two autoinhibitory regions, which interfere with the function of the catalytic domain: autoinhibitory segment (AIS) and autoinhibitory domain (AID). The AIS interacts with a hydrophobic intersubunit groove formed at the junction of CNA and CNB, and disruption of the AIS interaction results in partial stimulation of CN activity. In addition, the binding partner calmodulin regulates the orientation of AID with respect to the catalytic core, resulting in incomplete activation of CN.

Autoinhibitory domains (AIDs)

250-384 (RD domain) SS

Target domain

378-605 (ART domain)

Relief mechanism

Ligand binding, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q0JMY1

Entry ID Method Resolution Chain Position Source
No available structures

No variants for Q0JMY1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0JMY1

No associated diseases with Q0JMY1

5 regional properties for Q0JMY1

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 107 IPR006085
domain XPG-I domain 146 - 233 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 220 - 253 IPR008918
conserved_site XPG conserved site 79 - 93 IPR019974-1
conserved_site XPG conserved site 149 - 163 IPR019974-2

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Perikaryon
  • Cell projection, cilium
  • Cytoplasm
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name Definition
NAD+ ADP-ribosyltransferase activity Catalysis of the reaction
NAD+-protein ADP-ribosyltransferase activity Catalysis of the reaction
nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant.

1 GO annotations of biological process

Name Definition
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18493 PARP1 Poly [ADP-ribose] polymerase 1 Bos taurus (Bovine) SS
P26446 PARP1 Poly [ADP-ribose] polymerase 1 Gallus gallus (Chicken) SS
P35875 Parp Poly [ADP-ribose] polymerase Drosophila melanogaster (Fruit fly) SS
P09874 PARP1 Poly [ADP-ribose] polymerase 1 Homo sapiens (Human) SS
Q9Y6F1 PARP3 Protein mono-ADP-ribosyltransferase PARP3 Homo sapiens (Human) PR
Q9UGN5 PARP2 Poly [ADP-ribose] polymerase 2 Homo sapiens (Human) EV
O50017 PARP2 Poly [ADP-ribose] polymerase 2 Zea mays (Maize) SS
P11103 Parp1 Poly [ADP-ribose] polymerase 1 Mus musculus (Mouse) SS
O88554 Parp2 Poly [ADP-ribose] polymerase 2 Mus musculus (Mouse) SS
P27008 Parp1 Poly [ADP-ribose] polymerase 1 Rattus norvegicus (Rat) SS
Q5Z8Q9 PARP2-A Poly [ADP-ribose] polymerase 2-A Oryza sativa subsp. japonica (Rice) SS
Q9ZP54 PARP1 Poly [ADP-ribose] polymerase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q11207 PARP2 Poly [ADP-ribose] polymerase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q5RHR0 parp1 Poly [ADP-ribose] polymerase 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MASTSAGQNS AAKPDTTNTT TTASNNNRER ERDLKQFTER FVKTVQFPVS ERLTVDQVYD
70 80 90 100 110 120
RRTGKPRHEV LRDHFIKEGR IEEEAAIRVI QECSSLFRNE KTMLEIEAPV TVCGDIHGQF
130 140 150 160 170 180
YDLMKLFEVG GSPATTKYLF LGDYVDRGYF SIECVLYLWA LKICYPTTLF LLRGNHECRH
190 200 210 220 230 240
LTEYFTFKQE CKIKYSERVY DVCMESFDAL PLAALMNQQF LCVHGGLSPE IHTLEDIRRI
250 260 270 280 290 300
DRFKEPPAFG PMCDLLWSDP LEDFGNERNS EQFSHNSVRG CSYFYSYAAC CDFLQHNNLL
310 320 330 340 350 360
SIIRAHEAQD AGYRMYRKSQ ATGFPSLITI FSAPNYLDVY NNKAAILKYE NNVMNIRQFN
370 380 390 400 410 420
CSPHPYWLPN FMDVFTWSLP FVGEKVTEML VHILNICSDD ELMAECDDTF EGGVGSARKE
430 440 450 460 470 480
VIRHKIRAIG KMARAFSVLR HESESVLQLK GLNAGGKLPQ GALSEGRTGL NAAYRIEQSV
490 500 510 520 530 540
AAESGCDSGH LIQSFEEARR LDKINERMPP TMATPPAQSP SQSPIPSRQT TPQPPQNGPS
NS