Q0HFL0

PR
Gene name
hldE
Protein name
Bifunctional protein HldE
Names
Species
Shewanella sp (strain MR-4)
KEGG Pathway
she:Shewmr4_3086
EC number
2.7.1.167: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-361 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0HFL0

Entry ID Method Resolution Chain Position Source
AF-Q0HFL0-F1 Predicted AlphaFoldDB

No variants for Q0HFL0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0HFL0

No associated diseases with Q0HFL0

6 regional properties for Q0HFL0

Type Name Position InterPro Accession
conserved_site Carbohydrate/purine kinase, PfkB, conserved site 51 - 74 IPR002173-1
conserved_site Carbohydrate/purine kinase, PfkB, conserved site 258 - 271 IPR002173-2
domain Cytidyltransferase-like domain 343 - 470 IPR004821
domain Carbohydrate kinase PfkB 11 - 302 IPR011611
domain RfaE bifunctional protein, domain I 6 - 312 IPR011913
domain RfaE bifunctional protein, domain II 333 - 472 IPR011914

Functions

Description
EC Number 2.7.1.167 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
heptose 7-phosphate kinase activity Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP.
heptose-1-phosphate adenylyltransferase activity Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose.
phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

1 GO annotations of biological process

Name Definition
ADP-L-glycero-beta-D-manno-heptose biosynthetic process The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVSLPAFEK AKVLVVGDVM LDRYWVGPTG RISPEAPVPV VKINQVEDRP GGAANVALNI
70 80 90 100 110 120
ATLGGQVQLA GLVGEDDTAK ALTLGVQALG VEPQWLKIAD KPTITKLRVL SRNQQLIRLD
130 140 150 160 170 180
FEESFDKQDS ARLLKQSEAL LDSVDVVVLS DYAKGAIDKP QDFIALARAK GVKVLVDPKG
190 200 210 220 230 240
SDFSRYHGAS LITPNMSEFE AVVGAVTSEA DLLEKARGLL NKHQFDAILV TRSEKGMTLV
250 260 270 280 290 300
TANAPELHIP TVAREVYDVT GAGDTVISAL ATSLAAGAEL PQACAIANTA AGVVVGKLGT
310 320 330 340 350 360
STVSRIELIE ALALHHGESG FGVVSEDQLA YALEQAKLRG ERVVMTNGCF DILHAGHVSY
370 380 390 400 410 420
LKQAKALGDR LIVAVNDDAS VKRLKGEGRP VNQVDRRMAV LAGLAAVDWV VPFSEDTPQR
430 440 450 460 470
IIARLLPDLL VKGGDYKIED IAGGAEVIAA GGQVQVLGFE DGISTTAIIQ NIMAKQ