Q0CUP6

PR
Gene name
tif32 (ATEG_02588)
Protein name
Eukaryotic translation initiation factor 3 subunit A
Names
eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog
Species
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

858-1040 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0CUP6

Entry ID Method Resolution Chain Position Source
AF-Q0CUP6-F1 Predicted AlphaFoldDB

No variants for Q0CUP6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0CUP6

No associated diseases with Q0CUP6

1 regional properties for Q0CUP6

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 339 - 536 IPR000717

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPPPHIKPE NVLKRAQELI AVGQAPAALN VLHEHVTSKR TRSSPISSLE PVMLQIVELC
70 80 90 100 110 120
VDMRKGKAAK DGLYQYKNIA QNTNVGTIEV VLKKFIELAE KKVTEAQTKA DEIQSSLESA
130 140 150 160 170 180
APSANVEDLE AIETPETILL ATVSGEQSRD RTDRAVVTPW LKFLWETYRT VLEILKNNAR
190 200 210 220 230 240
LEVMYQTTAL QAFQFCLKYT RKTEFRRLCE LLRNHVQNAA KYSAQMHAIN LSDPDTLQRH
250 260 270 280 290 300
LDTRFQQLNV AVELELWQEA FRSIEDIHTL LSLSKRPAKN VMMANYYEKL ARIFLVSENY
310 320 330 340 350 360
LFHAAAWSRY YNLLRQSAAT LAAGQGTKKE NPSVTEADMT KAASFVLLSA LAIPVISTSR
370 380 390 400 410 420
SRGALVDVDE VRKNKNTRLT NLLGMAQPPT RAVLFKDAMN KGLLKRARPE IRELYNILEV
430 440 450 460 470 480
DFHPLSICKK ITPILKQIGS DPEMEKYVVP LQQVILTRLF QQLSQVYESV ELKFVYELAQ
490 500 510 520 530 540
FPDPFQITPA MIEKFIMNGC KKGDLAIRVD HISGVLTFDS DVFSSAKALH PGSAAGSAES
550 560 570 580 590 600
EVGSVQRLQN TPAEIARLQL TRLAKTLHVS CMYVDPSYNE SRIQAKQTAQ ARALAGAAKE
610 620 630 640 650 660
HEETLARRVI IEKKKEAATD ALQRKQREEE TRKRIRTQQL QEAEKQRLLD EQREREKKRI
670 680 690 700 710 720
KDEQDRIRQQ ELKKQLEELK SGVKGIDINE IDLQDLDANR LRAMKLAQLE KEKNELNDRI
730 740 750 760 770 780
RTTGKRIDHL ERAFRREELK HIPEDYEAQK KRDMEIYEAT KAETLKEAEL KHKEAVALKH
790 800 810 820 830 840
RLSRLVPHFN SFRKEVSEKR HEEFEKRRKA AERDFEAKKK QRVKEVQERR RREKMEREMA
850 860 870 880 890 900
ERQRKEEEER AQREEEEKRA RDEERRRVLA EEKAKREEER KRLDEIAAKQ KQREEEAEAR
910 920 930 940 950 960
RAARKAGLEP AAPAARPEPT ERTAPRLNIA PRTGGPSWRE RQAAKEAAGG AAPEAAPKEE
970 980 990 1000 1010 1020
APQPARRPGG YVPPHLRSGS SAAPAAPPSN GAPERYVPRH ARESSSSQPP SRTQTPGSDK
1030
PSEGGSAGKW VPRWKQQQNQ