Q0BST5

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
KEGG Pathway
gbe:GbCGDNIH1_1219
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0BST5

Entry ID Method Resolution Chain Position Source
AF-Q0BST5-F1 Predicted AlphaFoldDB

No variants for Q0BST5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0BST5

No associated diseases with Q0BST5

1 regional properties for Q0BST5

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 297 - 543 IPR000195

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDHTNPPSA PPDDDPNGGS LLMPVTLEEE MSRSYLDYAM SVIVSRALPD ARDGLKPVHR
70 80 90 100 110 120
RILYGMQESG YTADKPYRKS ARINGDVMGK YHPHGDAAIY DALVRLAQPF SLRVPLIDGQ
130 140 150 160 170 180
GNFGSMDGDP AAAPRYTEAR LARSASFLLN DIDRDTVDFQ PNYDDSEMEP RVLPASYPNL
190 200 210 220 230 240
LVNGADGIAV GMATKIPTHN PTEVIDATLA MIDNPDITLD ELMTVIPGPD FPTGGLILGR
250 260 270 280 290 300
SGIRSAFETG KGSITVRART DFEEVRGGRQ AIVISEIPYQ VNKATLQERM AELVRAKQIE
310 320 330 340 350 360
GISDIRDESD RSGVRVVIEL KRDATPDVVL NHLFRFTQLQ ISYGINMLAL DGGQPRLMGL
370 380 390 400 410 420
RDVLSTFIRF REDVILRRAR FELNKARDRA HLLVGLAIAV ANIDEVIRLI RQSPDSTSAR
430 440 450 460 470 480
IALMERDWPA ADVAPLLTLI DDGGNVLTEA QTVRLTEVQA RGILELRLQR LTGLERDKIH
490 500 510 520 530 540
NEMQEVAARI GELLEIIGSH IRRMEVMREE LAVIRAELNS PRRSEINDSL ADQDDESLIE
550 560 570 580 590 600
PGQMVVTITR DGFIKRTPLD VFRQQHRGGR GRAAASMRGD DIVTRSFNAH THQWVLFFSS
610 620 630 640 650 660
GGKAYRQKVW RLPEAGPTAK GRALVNLLPE LGSDGITAVL PLPQDESLWE GLHLVFATAS
670 680 690 700 710 720
GGIRRNRLSD FKNVRASGLI AMKLDEGDRL IGVATCREGD DIMLASRLGR CIRFQANEDT
730 740 750 760 770 780
LRVFAGRESS GVRGMKLAQG DEVISLSVLR HVEATPEERA AYLRYASARR RSAAGEEDQI
790 800 810 820 830 840
DAEVMEADDS EVTVDDTALS PERIAGLEEA EEFLLTVTIA GFGKRSSAYD YRVSGRGGQG
850 860 870 880 890 900
IANINLAPRN GRAVAATFPV RPGDDVMLVT DAGRLIRVPA DQVRITGRST MGVTLFRVDK
910 920 930
DEVVTSVFPV LETESVDDNG DDADSVAPAA PDGQVTDSDD