Q0AWK4

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Syntrophomonas wolfei subsp wolfei (strain DSM 2245B / Goettingen)
KEGG Pathway
swo:Swol_1599
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

242-330 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0AWK4

Entry ID Method Resolution Chain Position Source
AF-Q0AWK4-F1 Predicted AlphaFoldDB

No variants for Q0AWK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0AWK4

No associated diseases with Q0AWK4

5 regional properties for Q0AWK4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 420 - 621 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 666 - 781 IPR013155
domain Methionyl/Leucyl tRNA synthetase 41 - 181 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 406 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDRKYDFKSI EAKWQAYWEN KQLFKVEEDP EKPKYYNLEM FPYPSGHLHM GHVRNYAIGD
70 80 90 100 110 120
VVARFKSMNG FNVLHPMGWD AFGLPAENAA IKNAIHPATW TYSNIENMKR QLKTMGISYD
130 140 150 160 170 180
WDRELATCKP DYYKFTQWMF LKLYENKLAY KKKSAVNWCP SCQTVLANEQ VVDGACERCE
190 200 210 220 230 240
AVIEKKQLEQ WFFKITDYAQ RLLDDLALLP GWPEKVKTMQ KNWIGRSEGC EFSLHIEDSD
250 260 270 280 290 300
EVLTVFTTRP DTVFGVTYMV LAPEHPLVEK ICHPEQEKEV KAFVNKMKYL NEMARTSTEA
310 320 330 340 350 360
EKEGVFTGAY AINPMDGSRI PIWIANYVLM DYGTGAIMAV PAHDQRDFEF ARKYDIPVKV
370 380 390 400 410 420
VIKGEDTPLD GNLLQESYPG DGHMVNSGNF DGLTVEEGQK AVIKFMEEKG IGQGTVNYRL
430 440 450 460 470 480
RDWLISRQRY WGAPIPIVYC PECGPVAVPE EELPLYLPED IDFKPYAESP LKHLERFYKT
490 500 510 520 530 540
TCPSCGKEAL RETDTMDTFV CSSWYFDRFC SPHESKQPFS REAVDYWMPV DQYIGGVEHA
550 560 570 580 590 600
ILHLMYARFF TKFLFDINVL SCQEPFTRLL TQGMVLKDNA KMSKSKGNVV SPEEIIDTYG
610 620 630 640 650 660
ADTARLFILF ASPPERDLEW SEQGVEGAFR FLNRVWRLVS ELAEGIKDLP AAEHFPELDS
670 680 690 700 710 720
EAKNLRFKTH ATIKKVTEDI GERFNFNTAI SAIMELSNTL GAYKGIKKPN WPVVKEAVDN
730 740 750 760 770 780
LLILLSPFSP HICEELWQLT GHAESIYLQK WPKYDPEALL QEEIEIVLQI SGKVRDRIMV
790 800 810 820
PVDAGREELE KIALDNPKIR ELTRGKEIVK LIVVPGKLVN VVAK