Q0AUH2

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Syntrophomonas wolfei subsp wolfei (strain DSM 2245B / Goettingen)
KEGG Pathway
swo:Swol_2341
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

364-433 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0AUH2

Entry ID Method Resolution Chain Position Source
AF-Q0AUH2-F1 Predicted AlphaFoldDB

No variants for Q0AUH2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0AUH2

No associated diseases with Q0AUH2

7 regional properties for Q0AUH2

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 587 - 973 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 826 - 838 IPR007121
domain RNA polymerase Rpb2, domain 7 975 - 1049 IPR007641
domain RNA polymerase Rpb2, domain 2 139 - 322 IPR007642
domain RNA polymerase, beta subunit, protrusion 27 - 368 IPR007644
domain RNA polymerase Rpb2, domain 3 381 - 449 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 459 - 526 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAHLEQFGRV SRLSYSRIKE PVELPNLIQI QKNSYDWFLE HGLREALQEV FPISDFTGNL
70 80 90 100 110 120
ELGFLDYSMG EPKYSINECK ERDVSYQAPL KLKVRLTDKE NGEIKESEVY MGDLPLMTEK
130 140 150 160 170 180
GTFIINGAER VVVSQLVKSP GVYFNERMDV AGHPLFGATI IPNRGAWFEL EMDSAGLVYT
190 200 210 220 230 240
RIDKTRKIPV TVLLRALGYE SNEVILDMYD GDETIARTLE KDTSTNKKEA LIEFYRRLRP
250 260 270 280 290 300
GELATEDAAE QLLKNLFFDP RRYDMAAVGR YKVNKKLGLN IPPENRHLTL EDITATIGYL
310 320 330 340 350 360
LKLIKGEGKT DVIDHLGNRR LRSIGELLQN QFRTGLVRME RVVRERMSIH DVETLTPQVL
370 380 390 400 410 420
INIRPITAAV KEFFGSSQLS QFMDQTNPLA ELTHKRRLSA LGPGGLTRER AGFQVRDVHH
430 440 450 460 470 480
SHYGRICPIE TPEGPNIGLI GYLATFGQVN DFGFIETPYR KVDKKLGRVL NEIVYLSADE
490 500 510 520 530 540
EDEYYVAQAN APLDENGYFI EEKVEARYFE EILEIPKNRV DYMDVSPKQV FSVATALIPF
550 560 570 580 590 600
LENDDANRAL MGANMQRQAV PLVKTEAPIV GTGLEHKAAR DSGAVVIAKK AGTVKKASAS
610 620 630 640 650 660
RISIEKDDGT IDNYELLKFM RSNQGTCYNQ RPIVKVGERV EANEVIADGP STEQGELALG
670 680 690 700 710 720
RNVMVAFMPW EGYNYEDAIL ISEKLVKDDV FTSIHIEEYE CEARDTKLGS EEITRDIPNV
730 740 750 760 770 780
SEDMLKNLDD QGVIRVGAEV RPDDILVGKV TPKGETELTP EERLLRAIFG EKAREVRDSS
790 800 810 820 830 840
LRVPHGEAGK VVAVKRFSRE KGDELPPGVN QLVRVYIAQK RKISEGDKMA GRHGNKGVIS
850 860 870 880 890 900
RILPEEDMPF LEDGTPVEIV LNPLGVPSRM NIGQILECHM GWAARALGLN IATPVFDGAN
910 920 930 940 950 960
EEDIFTKLRE ASLLESGKTI LFDGRTGEKF KHEITVGYVY MLKLAHLVDD KIHARSIGPY
970 980 990 1000 1010 1020
SLVTQQPLGG KAQFGGQRFG EMEVWALEAY GSSYTLQEIL TVKSDDVAGR LKTYESIVKG
1030 1040 1050 1060 1070 1080
ENIPEPGVPE GFKVLIKELQ SLALDVRILA GDDHEILIKD NDNEGNEKEK ARELGLDLPD
1090 1100
NPVGRMLEIT QPIENAEQDV ELKSSPK