Q0AJA3

PR
Gene name
ruvB
Protein name
Holliday junction ATP-dependent DNA helicase RuvB
Names
Species
Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57)
KEGG Pathway
net:Neut_0284
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0AJA3

Entry ID Method Resolution Chain Position Source
AF-Q0AJA3-F1 Predicted AlphaFoldDB

No variants for Q0AJA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0AJA3

No associated diseases with Q0AJA3

4 regional properties for Q0AJA3

Type Name Position InterPro Accession
domain AAA+ ATPase domain 51 - 178 IPR003593
domain RuvB C-terminal winged helix domain 256 - 322 IPR008823
domain RuvB-like P-loop domain 20 - 178 IPR008824
domain RuvB, AAA lid domain 181 - 254 IPR041445

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
four-way junction helicase activity Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIESDRIITA SPFSSQEEVI ERALRPVQLD DYVGQEKIRE QLKIFIEAAR QRQEALDHVL
70 80 90 100 110 120
LFGPPGLGKT TLAHIIAREM GVNLRHTSGP VLERAGDLAA LLTNLEANDV LFIDEIHRLS
130 140 150 160 170 180
PVVEEILYPA MEDYQLDIMI GEGVAARSVK IDLPSFTLVG ATTRAGMLTN PLRDRFGIVS
190 200 210 220 230 240
RLEFYTSDEL SKIVTRSAGL LDVDITADGA REIACRSRGT PRIANRLLRR VRDFAEVRAN
250 260 270 280 290 300
GRIDRQVADA ALQMLDVDAA GLDVLDRKLL LAVLEKFGGG PVGVDNLAAA INEERDTIEE
310 320 330 340
VLEPYLIQQG FLQRTPRGRM ATTMTYQHFD IIPLQQAATP GLFNPD