Q09YI9

PR
Gene name
MET
Protein name
Hepatocyte growth factor receptor
Names
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Species
Ovis aries (Sheep)
KEGG Pathway
oas:443076
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

941-1080 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1222-1249 (Activation loop from InterPro)

Target domain

1079-1346 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q09YI9

Entry ID Method Resolution Chain Position Source
AF-Q09YI9-F1 Predicted AlphaFoldDB

No variants for Q09YI9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09YI9

No associated diseases with Q09YI9

11 regional properties for Q09YI9

Type Name Position InterPro Accession
domain Protein kinase domain 1079 - 1346 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 1079 - 1337 IPR001245
domain Sema domain 27 - 516 IPR001627
domain IPT domain 563 - 656 IPR002909-1
domain IPT domain 657 - 740 IPR002909-2
domain IPT domain 742 - 837 IPR002909-3
domain IPT domain 839 - 935 IPR002909-4
active_site Tyrosine-protein kinase, active site 1201 - 1213 IPR008266
domain PSI domain 520 - 563 IPR016201
binding_site Protein kinase, ATP binding site 1085 - 1111 IPR017441
domain Tyrosine-protein kinase, catalytic domain 1079 - 1338 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
protein phosphatase binding Binding to a protein phosphatase.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

14 GO annotations of biological process

Name Definition
branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
negative regulation of guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
negative regulation of hydrogen peroxide-mediated programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
negative regulation of Rho protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
negative regulation of stress fiber assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
negative regulation of thrombin-activated receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKAPAVLAPG ILVLLFTFVQ KSNGECKEAL VKSRMNVNMQ YQLPNFTAET SIRNVVLHKH
70 80 90 100 110 120
HIYLGAINYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL
130 140 150 160 170 180
LVDTYYDDQL ISCGSVHRGT CQRHVLPPNN TADIESEVHC MYSPQEDEET NQCPDCVVSA
190 200 210 220 230 240
LGTKVLLSEK ERFINFFVGN TINSSYFPDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
250 260 270 280 290 300
ELQDSYPIKY VHAFESNHFI YFLTVQRETL DAQTFHTRII RFCSADSGLH SYMEMPLECI
310 320 330 340 350 360
LTEKRRKRST KQEVFNILQA AYVSKPGAQL ARQIGANLND DILYGVFAQS KPDSSEPMNR
370 380 390 400 410 420
SAVCAFPVKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRNDEYRTE
430 440 450 460 470 480
FTTALPRIDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSLTPHVNF
490 500 510 520 530 540
PLDSHPVSPE VVVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPSFVQCG
550 560 570 580 590 600
WCHDKCVRLE ECPSGRWTQE TCLPTIYKVF PTSAPLEGGT TLTVCGWDFG FKRNNKFDLK
610 620 630 640 650 660
KTRVLLGNES CTLTLSESTT NMLKCTVGPA TNEHFNMSIV ISNSRGSVQY SMFSYVDPII
670 680 690 700 710 720
TSISPNYGPK TGGTLLTLTG KHLNSGNSRH ISIGGKTCTL KSVSYSILEC YTPAQSAPTE
730 740 750 760 770 780
FSVKLKIDLA NREVNSFIYR EDPIVYEIHP TKSFISGGST ITGVGKNLNS VSIIRMVINV
790 800 810 820 830 840
HEAGKNFTVA CQHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP
850 860 870 880 890 900
VFKPFEKPVM ISIGNENVLE IKGNDIDPEA VKGEVLKVGN KSCENIQSHS EAVLCTVPND
910 920 930 940 950 960
LLKLNSELNI EWKQAISSTV LGKVIVQPDQ NFTGLIVGVV SVSIILLLLL GLFLWLKKRK
970 980 990 1000 1010 1020
QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
1030 1040 1050 1060 1070 1080
SCRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH
1090 1100 1110 1120 1130 1140
FNEVIGRGHF GCVYHGTLLD NDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV
1150 1160 1170 1180 1190 1200
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMEYLASKK
1210 1220 1230 1240 1250 1260
FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK
1270 1280 1290 1300 1310 1320
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
1330 1340 1350 1360 1370 1380
WHPKAELRPS FSELVSRIAA IFSAFIGEHY VHVNATYVNV RCVAPYPSLL SSQENVSGED
DDDT