Q09915

PR
Gene name
spt6 (SPAC1F7.01c, SPAC694.07c)
Protein name
Transcription elongation factor spt6
Names
Chromatin elongation factor spt6
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1F7.01c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09915

Entry ID Method Resolution Chain Position Source
AF-Q09915-F1 Predicted AlphaFoldDB

15 variants for Q09915

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4216660_G_T 48 D>E No Jeffares_SNPs
I_4215968_T_G 279 K>T No Jeffares_SNPs
I_4215890_C_T 305 R>H No Jeffares_SNPs
I_4215746_G_T 353 T>K No Jeffares_SNPs
I_4215657_T_C 383 I>V No Jeffares_SNPs
I_4215561_C_T 415 D>N No Jeffares_SNPs
I_4215452_C_T 451 R>K No Jeffares_SNPs
I_4215359_A_G 482 V>A No Jeffares_SNPs
I_4214985_G_A 607 L>F No Jeffares_SNPs
I_4214934_C_T 624 A>T No Jeffares_SNPs
I_4214789_G_T 672 A>D No Jeffares_SNPs
I_4214316_C_T 830 D>N No Jeffares_SNPs
I_4214208_T_A 866 N>Y No Jeffares_SNPs
I_4214076_T_G 910 M>L No Jeffares_SNPs
I_4213868_T_C 979 E>G No Jeffares_SNPs

No associated diseases with Q09915

1 regional properties for Q09915

Type Name Position InterPro Accession
domain Lethal giant larvae (Lgl)-like, C-terminal domain 549 - 943 IPR013905

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).
transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

5 GO annotations of biological process

Name Definition
co-transcriptional chromatin reassembly The reestablishment of chromatin structure that was disrupted upon passage of RNA polymerase II during transcription elongation. This process prevents cryptic intragenic transcription initiation.
mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSENEVVGSP TTNGDKNEDG YPAENGEGTN VDDNNNEEEK DGIPLDNDND ENDSSEESAT
70 80 90 100 110 120
DEEAERQVRE GFIVEDEEDE VPQEIRRKKK RKKHAESTAD QDMLDEEDLE LVMENTGQGS
130 140 150 160 170 180
RFSKLRRLKR GRDQEETLEN IFSEEEEEEE NEVDDEAPNR TQGHRAGVID EFADFIEQDE
190 200 210 220 230 240
FEDEERQEEK YETGPPIESV RPEALGISDD DYIQIYEVFG DGTDYAFALE DEDAEDELEE
250 260 270 280 290 300
SVSLKTIFEP SELKDKMLTE EDEIIRITDE PERMQLYMKR NIDCSEDEFR EQVAWIIDYL
310 320 330 340 350 360
LKNRRDIDAE LYEPFQTAVR YVVHFFIRDS LEVPFIWQHR RDYIVHNNRE RNTITPLLSQ
370 380 390 400 410 420
NDLWNIFFLC TKFWSLHSKK QDILKLYSDL GINDDLVVPF CEAASSLDAI DDLNDYIHFT
430 440 450 460 470 480
YSEQIRDRAL LMGTGLRRPQ GSKYSFFEKF RKSSLYNLVK EFGMSAKDFS FNVAQGARLR
490 500 510 520 530 540
FVEDNTLSPE ELSRTYVTNE LSSPEQVLQK ARRVLAEEII HDPQFRKSFR DKLYNAGVVT
550 560 570 580 590 600
VLATQKGVRK IGSEHPYYEF KYLKRKPLGS FELEPILFLK MLKAEEEGLI QLSIEFEDPD
610 620 630 640 650 660
DVFKGLLELF VSDNFSENAM QWNAQRELVL KEVFKRFSAL APDAIRETLR SRYLDELGMR
670 680 690 700 710 720
CRNQLFSRLD QAPYEPSTKN FDRGTIPSVL AVSNGKGESS DAIICVFVDD VGEPTDSLKL
730 740 750 760 770 780
ADLRDLANQA MFAEFVEKVK PDVIGVSGMS VSAHKIRQHV QDSLTSHEPV DLIMVNDEVA
790 800 810 820 830 840
RLYQNSTRAV DEFPTLPTIS CYCVALARYV QNPLFEYAAM GRDLMSLSFD PWQHLLPPDV
850 860 870 880 890 900
LWKYLETALV DISSLVGIDI NEAVTNKYEA NILPYIAGLG PRKADYVLKK IAATGGRIDN
910 920 930 940 950 960
RSDLISKQIM SRKVFINCSS FFIIPNDEYP NMDILDSTRI HNEDYELARK MASDALELDE
970 980 990 1000 1010 1020
EDIEELETNR GVVYHLLEEN ETGKLDELVL EEYADQLERE FHQKKRNTLE KIRLELKDPY
1030 1040 1050 1060 1070 1080
GEQRNVFHKL TPSEIFLMLT GENPEELQAD AIVPVNVRRV TNRFVAVKLD CGIDGNIKAD
1090 1100 1110 1120 1130 1140
EVSDDFIPPP QLLQVGQTVE GVIISLDEAN FMVDLSLRNS VLQSANSKRQ TSSHRTSYWD
1150 1160 1170 1180 1190 1200
TEAEKRDTER MQAETQAEQR VARVIKHPLF KDLNASQAEA YLSKMQVGDL VIRPSSKGSD
1210 1220 1230 1240 1250 1260
HIVVTWKVAE GSYQHIDVLE LEKENEFTIG QKLLVKGRFE KMTYQYSDLD ELIVLHIKAI
1270 1280 1290 1300 1310 1320
AKKIDEMCIH DKFRKGTQAE TEKWLESYSE ANPKRSCYAF CFDHQHPGYF ILCFKASVNS
1330 1340 1350 1360
PVTAWPVKVI PNAFFLQGNV YGDMTALCNG FKLLYAARTK NFRRM