Q09842

PR
Gene name
pdp3 (SPAC23D3.01)
Protein name
PWWP domain-containing protein 3
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC23D3.01
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-264 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09842

Entry ID Method Resolution Chain Position Source
AF-Q09842-F1 Predicted AlphaFoldDB

14 variants for Q09842

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4337277_A_T 10 K>N No Jeffares_SNPs
I_4337294_T_A 16 I>N No Jeffares_SNPs
I_4337311_A_G 22 I>V No Jeffares_SNPs
I_4337351_A_G 35 N>S No Jeffares_SNPs
I_4337354_C_T 36 T>M No Jeffares_SNPs
I_4337689_G_A 148 V>I No Jeffares_SNPs
I_4337801_C_T 185 P>L No Jeffares_SNPs
I_4337858_A_C 204 N>T No Jeffares_SNPs
I_4337893_A_C 216 K>Q No Jeffares_SNPs
I_4337930_T_C 228 M>T No Jeffares_SNPs
I_4337944_G_A 233 A>T No Jeffares_SNPs
I_4338065_T_C 273 I>T No Jeffares_SNPs
I_4338373_C_A 376 Q>K No Jeffares_SNPs
I_4338392_G_A 382 S>N No Jeffares_SNPs

No associated diseases with Q09842

1 regional properties for Q09842

Type Name Position InterPro Accession
domain PWWP domain 61 - 139 IPR000313

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
NuA3 histone acetyltransferase complex A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
double-stranded DNA binding Binding to double-stranded DNA.
methylated histone binding Binding to a histone in which a residue has been modified by methylation.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

3 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMVARTRSQK RKLEEINNQK KIKTKKKATG QQTSNTKNLR DVKKKGKQLA YVPRTSPRKS
70 80 90 100 110 120
YKNGEYVLAK MSSFPWWPAR VASQKSIPTE VRERLKRNFR MDNGIFVQFL PSRDYAIISS
130 140 150 160 170 180
SNVLPLTVDE SRFILDHDLS TKYIQKTVGL IIASVKRKVS FSDVEEDEFE PENTRKKLQK
190 200 210 220 230 240
PIEKPKKEKI EATPKIDGGK RLKNEKSSAE ISQTSKQRPS RRSARVRMAT DNAQKSPSPI
250 260 270 280 290 300
PSPKKTAKKR VRFAGSLEEL PKFSLEYQLA QPISTVDMYA QVHYIRFNTL LYYRYQLQEI
310 320 330 340 350 360
LLSYNHYPQE SDMSHVHQIL EMIENFSAIN SELLESTKLY SLFTLLVKLS DIPLDEKYDF
370 380 390 400
SSRFSTLLLQ FQAFVQPKTM TSNVSTAPIG KNAQVNTEAA RPSVITT