Q09803
Gene name |
vps4 (SPAC2G11.06) |
Protein name |
Suppressor protein of bem1/bed5 double mutants |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC2G11.06 |
EC number |
3.6.4.6: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q09803
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q09803-F1 | Predicted | AlphaFoldDB |
2 variants for Q09803
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_818979_G_T | 210 | V>F | No | Jeffares_SNPs | |
| I_819509_G_C | 386 | E>D | No | Jeffares_SNPs |
No associated diseases with Q09803
7 regional properties for Q09803
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 161 - 296 | IPR003593 |
| domain | ATPase, AAA-type, core | 165 - 294 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 266 - 285 | IPR003960 |
| domain | MIT domain | 3 - 80 | IPR007330 |
| domain | Spastin/Vps4, C-terminal | 370 - 429 | IPR015415 |
| domain | AAA ATPase, AAA+ lid domain | 319 - 351 | IPR041569 |
| domain | Vacuolar protein sorting-associated protein 4, MIT domain | 5 - 79 | IPR045253 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.6 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| late endosome to vacuole transport | The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. |
| nuclear envelope organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
| vacuole organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNPDCLSKA | ISLVKTAIDN | DNAEQYPDAY | KYYQSALDYF | MMALKYEKNE | KSKEIIRSKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IEYLDRAEKL | KVYLQEKNNQ | ISSKSRVSNG | NVEGSNSPTA | NEALDSDAKK | LRSALTSAIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEKPNVRWDD | IAGLENAKEA | LKETVLLPIK | LPQLFSHGRK | PWSGILLYGP | PGTGKSYLAK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVATEAGSTF | FSISSSDLVS | KWMGESERLV | RQLFEMAREQ | KPSIIFIDEI | DSLCGSRSEG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESESSRRIKT | EFLVQMNGVG | KDESGVLVLG | ATNIPWTLDS | AIRRRFEKRI | YIPLPNAHAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARMFELNVGK | IPSELTSQDF | KELAKMTDGY | SGSDISIVVR | DAIMEPVRRI | HTATHFKEVY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DNKSNRTLVT | PCSPGDPDAF | ESSWLEVNPE | DIMEPKLTVR | DFYSAVRKVK | PTLNAGDIEK |
| 430 | |||||
| HTQFTKDFGA | EG |