Q09798

PR
Gene name
pan2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22G7.04
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

371-461 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09798

Entry ID Method Resolution Chain Position Source
AF-Q09798-F1 Predicted AlphaFoldDB

7 variants for Q09798

Variant ID(s) Position Change Description Diseaes Association Provenance
I_733239_G_A 91 R>K No Jeffares_SNPs
I_733627_A_G 168 N>S No Jeffares_SNPs
I_734013_C_T 297 H>Y No Jeffares_SNPs
I_734060_G_T 312 L>F No Jeffares_SNPs
I_735050_A_G 630 Y>C No Jeffares_SNPs
I_735611_A_G 805 I>V No Jeffares_SNPs
I_736338_A_G 1047 E>G No Jeffares_SNPs

No associated diseases with Q09798

3 regional properties for Q09798

Type Name Position InterPro Accession
domain Exonuclease, RNase T/DNA polymerase III 858 - 1042 IPR013520
domain PAN2, UCH domain 473 - 788 IPR028881
domain Ubiquitin specific protease domain 473 - 814 IPR028889

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

4 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDAWKEITKT TENDGVSTCS LSSIAFDPYS ELVWTGHKNG QIKSSFGPSL TSYTQFIGHE
70 80 90 100 110 120
GPVHQVLPQE RGVFSLSSKS LRLSNRKGTI RWRYQDSDCI DYRAMFYQSR NNPEVVIGGY
130 140 150 160 170 180
HQKLTVVNAE RGISIHKDKN VSDIFIMRRN RLLCCGSTNG EIILRDPNSF QPVNKVVAHT
190 200 210 220 230 240
GTISDIDTSG NLLLSCGYSL RHGTYMLDPF VKVWDLRNLS SLVPIPFPAG PTIIRMHPKL
250 260 270 280 290 300
STTAVVCSCS GQFHIVDTGN PLDAKLMQIP LTSYLTGMDI ASTGDAMVFT DVEDNIHLWS
310 320 330 340 350 360
PLENPSFSDL KLPIQLPNTS TETVQLENND PLNSIGLPYY KDELLSSWSK YLIFDVGKPI
370 380 390 400 410 420
LDSNLLIAKQ ISENSHPVPQ EIKSFHRNQI IEVPWLNRKL ISEGATPKFH SERQKDIMSG
430 440 450 460 470 480
NDIEGSASYF EEIEDTISGP DSIPKFYQRP VIKYSKFGIE DFDFGFYNKT KYAGLETDIT
490 500 510 520 530 540
NSYCNSVLQL LSYVPSFSKA AISHSLGPCD LMECLLCELG FLFAMLKEST GRNCQATNFL
550 560 570 580 590 600
RAFSNSSFAQ SLGIVFDDYS DGTFPDSFVI QKFTKFMLTE ISRIADYEDK KDGTSFPVSF
610 620 630 640 650 660
LLKSFCIPEM QTYRCGICGI TSQKIKSSLY IIDLHYPSQQ LESILSFEWL FKMSLDRRVD
670 680 690 700 710 720
LPPGWCEYCL AHQPFLLRSF IRSLPDCLFI NTQVKHHEHW KLWARKNWLP KKLHLRRVND
730 740 750 760 770 780
TMQCVSQKIS NLDKDQQSLS VYVLRGIIYE IRQNGEEPHF VSTIRVSDNT SSDNPDDNRW
790 800 810 820 830 840
YIFNDFLVKE VTEEEALTVH GPWKIPIIVY YEKLDTKIPQ WDEVSDYTLL YQPYSLNKNP
850 860 870 880 890 900
PINKIQPLTT DEMLYPKMLV GIDSEFVALQ QEETEVRSDG TKSTIKPSKL SLARVSVLRG
910 920 930 940 950 960
EGPNKGLPFI DDYVATDDKV TDYLTEYSGI HPGDLDPDRS PYNVVPLKVA YKKLRLLVNA
970 980 990 1000 1010 1020
GCIFVGHGLQ KDFRIINLLV PPEQVVDTVD LFFLSSRQRK LSLKFLAWYL LDEEIQLTEH
1030 1040 1050 1060 1070 1080
DSIEDALTAL KLYDCYDKLK SQGKLEETLD NIYEVGRRFK FRPPSVASMS LEDRNSYGDE
SVISNQTN