Q09792

PR
Gene name
ppk8 (SPAC22G7.08)
Protein name
Serine/threonine-protein kinase ppk8
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22G7.08
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-265 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

381-408 (Activation loop from InterPro)

Target domain

241-505 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q09792

Entry ID Method Resolution Chain Position Source
AF-Q09792-F1 Predicted AlphaFoldDB

9 variants for Q09792

Variant ID(s) Position Change Description Diseaes Association Provenance
I_750237_T_C 64 I>T No Jeffares_SNPs
I_750339_T_C 98 L>P No Jeffares_SNPs
I_750471_A_G 142 N>S No Jeffares_SNPs
I_750582_T_C 179 F>S No Jeffares_SNPs
I_750614_G_A 190 A>T No Jeffares_SNPs
I_750672_T_C 209 V>A No Jeffares_SNPs
I_750815_G_A 257 V>I No Jeffares_SNPs
I_750938_C_T 298 L>F No Jeffares_SNPs
I_751409_A_G 455 N>D No Jeffares_SNPs

No associated diseases with Q09792

3 regional properties for Q09792

Type Name Position InterPro Accession
domain Protein kinase domain 241 - 505 IPR000719
active_site Serine/threonine-protein kinase, active site 360 - 372 IPR008271
binding_site Protein kinase, ATP binding site 247 - 270 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVITEENSN NLFCTDSLEL TSNKQDDQVI SNYLKPVRSY PYIKYSRSSL LLTASTTLPE
70 80 90 100 110 120
NFVISFTNSI ESEESDKSDY LLDHAHSLQE LSTTHSSLSS TLTSMSEESS STESKFATLN
130 140 150 160 170 180
DGINGGNPYS RLYRKNPSSD PNDIPPQFHF KKKSKSFYSS MYDKMKIRIN ILPNGNDNFI
190 200 210 220 230 240
KKRNSGFALA PIACYNHTSD LRKLLKHKVT GSNASIFKRI NPRSRKRVVN PECSVTDTPY
250 260 270 280 290 300
GKLNNVIGEG ASSFIRVIND RNKLPIYVAK VFRPPLDTSL LRRYVRYFIA EYTFASTLRH
310 320 330 340 350 360
PNIIKVLDII YKRHTILQII EYVPYDLFTF ITKGHCSALK ADQMFFQLLD GVAYMHSLGI
370 380 390 400 410 420
AHRDIKLDNI MLDENLNVKI IDFGTAFVFH YPFESTTLMS DGVVGSKPYV APEVLTQKPY
430 440 450 460 470 480
DPSAVDVWSC AIVYCCIALK RFPWKVPHTS DKRFNLYVTQ RNDPNTKSQL IESLPMNSRD
490 500 510
TIYHMLDIDF NTRCSISGAR STTWMQQVRK TLI