Q09737

PR
Gene name
SPAC13A11.06 (SPAC3H8.01)
Protein name
Putative pyruvate decarboxylase C13A11.06
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
EC number
4.1.1.1: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

155-232 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09737

Entry ID Method Resolution Chain Position Source
AF-Q09737-F1 Predicted AlphaFoldDB

5 variants for Q09737

Variant ID(s) Position Change Description Diseaes Association Provenance
I_585765_G_A 57 G>S No Jeffares_SNPs
I_585986_T_G 130 D>E No Jeffares_SNPs
I_586131_G_A 179 A>T No Jeffares_SNPs
I_586996_A_G 467 N>S No Jeffares_SNPs
I_587154_T_C 520 C>R No Jeffares_SNPs

No associated diseases with Q09737

No regional properties for Q09737

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q09737

Functions

Description
EC Number 4.1.1.1 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
magnesium ion binding Binding to a magnesium (Mg) ion.
pyruvate decarboxylase activity Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

2 GO annotations of biological process

Name Definition
glycolytic fermentation to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGDILVGEY LFKRLEQLGV KSILGVPGDF NLALLDLIEK VGDEKFRWVG NTNELNGAYA
70 80 90 100 110 120
ADGYARVNGL SAIVTTFGVG ELSAINGVAG SYAEHVPVVH IVGMPSTKVQ DTGALLHHTL
130 140 150 160 170 180
GDGDFRTFMD MFKKVSAYSI MIDNGNDAAE KIDEALSICY KKARPVYIGI PSDAGYFKAS
190 200 210 220 230 240
SSNLGKRLKL EEDTNDPAVE QEVINHISEM VVNAKKPVIL IDACAVRHRV VPEVHELIKL
250 260 270 280 290 300
THFPTYVTPM GKSAIDETSQ FFDGVYVGSI SDPEVKDRIE STDLLLSIGA LKSDFNTGSF
310 320 330 340 350 360
SYHLSQKNAV EFHSDHMRIR YALYPNVAMK YILRKLLKVL DASMCHSKAA PTIGYNIKPK
370 380 390 400 410 420
HAEGYSSNEI THCWFWPKFS EFLKPRDVLI TETGTANFGV LDCRFPKDVT AISQVLWGSI
430 440 450 460 470 480
GYSVGAMFGA VLAVHDSKEP DRRTILVVGD GSLQLTITEI STCIRHNLKP IIFIINNDGY
490 500 510 520 530 540
TIERLIHGLH ASYNEINTKW GYQQIPKFFG AAENHFRTYC VKTPTDVEKL FSDKEFANAD
550 560 570
VIQVVELVMP MLDAPRVLVE QAKLTSKINK Q