Q09732
Gene name |
dcc1 (SPAC31A2.15c) |
Protein name |
Sister chromatid cohesion protein dcc1 |
Names |
Defective in sister chromatid cohesion protein 1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC31A2.15c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q09732
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q09732-F1 | Predicted | AlphaFoldDB |
6 variants for Q09732
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_419725_G_T | 3 | A>E | No | Jeffares_SNPs | |
| I_419498_C_T | 46 | V>I | No | Jeffares_SNPs | |
| I_419438_C_T | 66 | A>T | No | Jeffares_SNPs | |
| I_419012_A_G | 192 | I>T | No | Jeffares_SNPs | |
| I_419008_T_G | 193 | L>F | No | Jeffares_SNPs | |
| I_418925_T_C | 221 | N>S | No | Jeffares_SNPs |
No associated diseases with Q09732
No regional properties for Q09732
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q09732 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| Ctf18 RFC-like complex | A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| maintenance of mitotic sister chromatid cohesion | The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEANEERCIL | LKYPHPSSDI | SSEYLLLELD | DDLLKTLEEN | PEEEIVFKSD | FDKKASVLCT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDKTYAVRQV | VQSNSYLLFD | ELSPTDWVLN | DTCYSFLEVE | RIYGFIFSDD | KISYWDEDSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELKPISLTKD | QFIRSVPASR | NEVDSFLQKN | FFMVKNEFLY | RLSPSYICSI | IDWIFVIAQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LHIDFASFEF | KILKKPAMDD | EFDWDSVICV | LESISSPIKD | NVLPKKFNID | LELTTFWYGR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLLEGINSIS | SDEFIQLWDN | RLPYPCKGLP | SLNLLKGYYF | HDTPNTIQYL | SGDQLPREPS |
| 310 | 320 | 330 | 340 | 350 | |
| RRFQSLFQLK | SKWLYEELWS | FVKDLALSKS | RVEALILKYG | RKQTSRDGVY | INSRGTW |