Q09715

PR
Gene name
tup11 (SPAC18B11.10)
Protein name
Transcriptional repressor tup11
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC18B11.10
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09715

Entry ID Method Resolution Chain Position Source
AF-Q09715-F1 Predicted AlphaFoldDB

3 variants for Q09715

Variant ID(s) Position Change Description Diseaes Association Provenance
I_301630_T_C 28 S>G No Jeffares_SNPs
I_301446_T_C 67 I>V No Jeffares_SNPs
I_300380_T_C 365 T>A No Jeffares_SNPs

No associated diseases with Q09715

2 regional properties for Q09715

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 39 - 49 IPR001412
domain RNA-binding S4 domain 353 - 414 IPR002942

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription.

2 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

3 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.
negative regulation of transcription from RNA polymerase II promoter in response to iron Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASVEDATKV QEMLDALKAE YNALAHHSFA SKARGNDYES SMIQSQIQEI EAFRKTVDDM
70 80 90 100 110 120
YEKQKSIRET YEKDINKLKR ELEELGVEAN TASYRNRGER SELAASNNQV THIDQEHPSQ
130 140 150 160 170 180
TKSTSQPPSN HLPAFQQIPP IHQSAYPQNN VAEVLMPPIP PSVEASSGQN FNQGIASQNP
190 200 210 220 230 240
AISTSNLPST TPLYIPPVNY GANQVSQQPN PQLPGVSNYY NPSATSKPAV NVQPPRIPTK
250 260 270 280 290 300
ATPSAEPSMT ASANAGSISQ AGPDGEYQGR EQIAPVSDTE AARKTTSQSW YVTYNPACKR
310 320 330 340 350 360
VFNINLVHTL EHPSVVCCVK FSNNGKYLAT GCNQAANVFD VQTGKKLFTL HEESPDPSRD
370 380 390 400 410 420
LYVRTIAFSP DGKYLVTGTE DRQIKLWDLS TQKVRYVFSG HEQDIYSLDF SHNGRFIVSG
430 440 450 460 470 480
SGDRTARLWD VETGQCILKL EIENGVTAIA ISPNDQFIAV GSLDQIIRVW SVSGTLVERL
490 500 510 520 530 540
EGHKESVYSI AFSPDSSILL SGSLDKTIKV WELQATRSVG LSAIKPEGIC KATYTGHTDF
550 560 570 580 590 600
VLSVAVSPDS RWGLSGSKDR SMQFWDLQTG QSYLTCQGHK NSVISVCFSP DGRQFASGSG
610
DLRARIWSID PASP