Q09706

PR
Gene name
pld1 (SPAC2F7.16c)
Protein name
Phospholipase D1
Names
PLD 1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC2F7.16c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09706

Entry ID Method Resolution Chain Position Source
AF-Q09706-F1 Predicted AlphaFoldDB

16 variants for Q09706

Variant ID(s) Position Change Description Diseaes Association Provenance
I_569181_C_T 33 G>R No Jeffares_SNPs
I_569153_G_A 42 P>L No Jeffares_SNPs
I_568730_C_G 183 G>A No Jeffares_SNPs
I_568503_G_A 259 H>Y No Jeffares_SNPs
I_568398_G_T 294 Q>K No Jeffares_SNPs
I_568068_A_G 404 Y>H No Jeffares_SNPs
I_568047_A_C 411 L>V No Jeffares_SNPs
I_567884_G_A 465 A>V No Jeffares_SNPs
I_567746_T_C 511 Q>R No Jeffares_SNPs
I_567551_C_T 576 S>N No Jeffares_SNPs
I_566231_A_G 1016 L>S No Jeffares_SNPs
I_566085_A_T 1065 Y>N No Jeffares_SNPs
I_566031_T_C 1083 K>E No Jeffares_SNPs
I_565779_C_T 1167 D>N No Jeffares_SNPs
I_565730_A_G 1183 V>A No Jeffares_SNPs
I_565340_G_A 1313 T>I No Jeffares_SNPs

No associated diseases with Q09706

4 regional properties for Q09706

Type Name Position InterPro Accession
domain Phox homology 208 - 379 IPR001683
domain Phospholipase D/Transphosphatidylase 641 - 668 IPR001736-1
domain Phospholipase D/Transphosphatidylase 941 - 968 IPR001736-2
domain Phospholipase D-like domain 815 - 984 IPR025202

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

3 GO annotations of molecular function

Name Definition
N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.

6 GO annotations of biological process

Name Definition
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIHQGGNSV IDNVPYSLNT NVNDSIYSEK GTGRKDAEDH TPSKITDLEK NVDHSIPSFP
70 80 90 100 110 120
ENDPKNYSEF VNLNPPKRPD LEHTRGSSWH TASENVNDLA ANDSTRVQTP EFITQTMEDE
130 140 150 160 170 180
NVEVPPLERD ERDAAAAHTS KANRNSARQM WAQLMASVRK FKREDEKPIL KENLPAINLF
190 200 210 220 230 240
EAGIPASLPI AKHFIRDKSG QPVLPIITDL IKVSVLDVEP KHNRIHSTFT IQVEYGTGPH
250 260 270 280 290 300
AIRWLIYRQL RDFINLHSHF LFFEFQHRFS GRRMKLPKFP KEVLPYLVKL RGYQKILYSN
310 320 330 340 350 360
PSDQLIDETH SISDISWESH SQDGDRTTGQ PRHANNGRKK HGNFWTIQGN TLGVYLQEMI
370 380 390 400 410 420
HNLQFFPEVN VLYSFLEFSS LGLYLAGAGT FHGKEGFATL KRNYSPTQYM LCCNTTMMKT
430 440 450 460 470 480
RSQPFWIIVS ESCIILCDNM LSMQPADVFI WDVDFEITRK NFRKAHSKDT NEKIRLSHHS
490 500 510 520 530 540
FKIKNRQKVM KLSVRSGRWL QQFINSVQVA QGLTAWCEIH RFDSFAPVRT NVAVQWMVDA
550 560 570 580 590 600
RDHMWNVSRA IKNAKRCIMI HGWWLSPELQ MRRPYSMAHK WRIDRILNEK AHEGVMVYIM
610 620 630 640 650 660
IYRNIDATIP IDSFHTKEHL QSLHPNIYVI RSPSHFRQNA LFWAHHEKLV VVDDAITFIG
670 680 690 700 710 720
GIDLCFGRYD TPQHILYDDK PVADKTGLCE QTWRGKDYSN ARVHDFFDLT EPYKDMYDRL
730 740 750 760 770 780
AVPRMGWHDV SMCIIGQPAR DAARHFVQRW NYLIQCKKPA RKTPLLIPPP DFTTDQLTDS
790 800 810 820 830 840
QLTGTCEVQV LRSAGLWSLG LVDTVEQSIQ NAYVTCIEKS EHFIYIENQF FVTSTTCEGT
850 860 870 880 890 900
TIENRVGDAL VERIIRAHKN NEKWRGVIMI PLLPGFEGQI DLQEGGSLRL IVECQYRSIC
910 920 930 940 950 960
HGEHSIFGRL NAKGIDGSKY LRFYGLRGWA HLGENHELVT EMIYVHAKIL IADDRVAVIG
970 980 990 1000 1010 1020
SANINERSLL GNRDSEIAAV IRDTLTIDSK MDGKPYKVGK FAHTLRKRLM REHLGLETDV
1030 1040 1050 1060 1070 1080
LEQREYNMDG LDRDTEWKRV EVWTPDEGNA INGSAYTAEE LKMKYRSQSQ FTTTPDILRK
1090 1100 1110 1120 1130 1140
AEKSMKKLDQ RVSLIPSSIE FNIKTQKDKV EFEKNYEKSK KGPDVIANAL VGGIPLSLKT
1150 1160 1170 1180 1190 1200
KEDSLYELSK FSQCGEDQRP MVLKDPDHLV PEPSRPHCGN GLVFYDDIPL LEVNPISGET
1210 1220 1230 1240 1250 1260
IPKFDASSFE DPVCDEFFED IWSKVASNNT TIYRHIFRCV PDDEMLTWES YNEWKKYGKR
1270 1280 1290 1300 1310 1320
FKEEQARWRQ EELSNLHETH EKSENDPKNP KAGSQGSGNT SASEDSKTEK PKTRTNNGLQ
1330 1340 1350 1360
VPDKRVVYDL LRGIRGQLVE LPLKWMSTES NARNWLSSID KIPPLEIYD