Q09535
Gene name |
pch-2 (F10B5.5) |
Protein name |
Putative pachytene checkpoint protein 2 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F10B5.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q09535
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4XGU | X-ray | 230 A | A/B/C/D/E/F | 1-424 | PDB |
| AF-Q09535-F1 | Predicted | AlphaFoldDB |
No variants for Q09535
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q09535 | |||||
No associated diseases with Q09535
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| meiotic recombination checkpoint signaling | A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes. |
| reciprocal meiotic recombination | The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHEPMKTLKN | IHAEIRICQK | FPKSTVQKRF | SEFEELIKAA | SKNARNWKPI | SSVELFQGDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLNELFEKLV | IGTCELRDGE | LFENVNDLTI | NPSNIHVYKL | HKDGPLSQNI | GDDDGDESII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSQLWQLPCV | EFDSIWENLI | YDSNLKNEVM | SYVAALARLS | EKHVNTKIIN | VNRLILLTGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGTGKTSLCK | GLAQHLSIRM | NDKYSKSVML | EINSHSLFSK | WFSESGKLVQ | KMFDQIDELA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDEKCMVFVL | IDEVESLGMC | RESSSSRSEP | SDAIRAVNAL | LTQIDRIRRR | DNVLILCTSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LESTLDKALV | DRADIVKNVG | QPSDFARYSM | LKSSIMELAR | IGVVIDNEVH | TDYWPQDICD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TKAPRNEFTE | ILFKIAQEAR | GLSGRAISML | PTLVYSKSPE | ETITLPNCMN | LFLEAVKERL |
| SRNN |