Q09438

PR
Gene name
B0228.7
Protein name
S-methyl-5'-thioadenosine phosphorylase
Names
5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.4.2.28: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09438

Entry ID Method Resolution Chain Position Source
AF-Q09438-F1 Predicted AlphaFoldDB

No variants for Q09438

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09438

No associated diseases with Q09438

4 regional properties for Q09438

Type Name Position InterPro Accession
domain SH3 domain 375 - 438 IPR001452
domain IMD/I-BAR domain 1 - 250 IPR013606
domain I-BAR domain containing protein IRSp53, Inverse-Bin/Amphiphysin/Rvs domain 5 - 236 IPR030128
domain IRSp53, SH3 domain 378 - 436 IPR035594

Functions

Description
EC Number 2.4.2.28 Pentosyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
S-methyl-5-thioadenosine phosphorylase activity Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.

2 GO annotations of biological process

Name Definition
L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKVGIIGGS GLEDPNILLD PVTVAVDTPY GKPSDDVVEG TINGVECVLL ARHGRKHDIM
70 80 90 100 110 120
PGNVNFRANL WALYSRGVDV IIASTACGSL QENVEPGHLL FPDSVFDRTT GRQSTFFDGS
130 140 150 160 170 180
YDQAPGVCHI QAHPTYNEKL RQVLISTAER CQLVHHRTGF GVCIEGPRFS TKAESMVFKS
190 200 210 220 230 240
WGASLVNMTM MPECILAKEL GIPYATTALV TDYDCWKEED HVTASSVMKV FAANVEKAKT
250 260 270 280
LFVEAVGEIG KIDWSAEILK LKTEARESVM ISPDVVIPFL TTDNQKKF