Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08I43
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08I43-F1 | Predicted | AlphaFoldDB |
No variants for Q08I43
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q08I43 | |||||
No associated diseases with Q08I43
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| double-stranded RNA binding | Binding to double-stranded RNA. |
| double-stranded RNA-specific ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| negative regulation of heterochromatin assembly by small RNA | Any process that decreases the frequency, rate or extent of small non-coding RNA-mediated heterochromatin formation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPVQILVW | PFPCDEMNQK | TPSTVEEIRI | ALQELGLSTN | GNKEKLKRRW | KFREKRLEEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKQERYQKFS | TSNENKTCLR | YLLIVDVEAT | CEEGCGFSFE | NEIIELPCLL | FDLIEKSIID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EFHSYVRPSM | NPTLSDYCKS | LTGIQQCTVD | KAPIFSDVLE | ELFIFLRKHS | NILVPSVDEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIIEPLKSVP | RTQPKNWAWA | CDGPWDMASF | LAKQFKYDKM | PIPDWIKGPF | VDIRSFYKDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRVPRTNING | MLEHWGLQFE | GSEHRGIDDA | RNLSRIVKKM | CSENVEFECN | RWWMEYEKNG |
| 310 | |||||
| WIPNRSYPPY | FAS |