Q08EC4
PR
Gene name |
Cass4 |
Protein name |
Cas scaffolding protein family member 4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320664 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08EC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08EC4-F1 | Predicted | AlphaFoldDB |
67 variants for Q08EC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27615088 | 4 | T>I | No | EVA | |
| rs248248899 | 5 | S>N | No | EVA | |
| rs3388614811 | 13 | T>S | No | EVA | |
| rs3388617906 | 24 | A>V | No | EVA | |
| rs3388612818 | 40 | I>V | No | EVA | |
| rs3388605110 | 91 | L>I | No | EVA | |
| rs224420857 | 92 | T>A | No | EVA | |
| rs33722333 | 96 | A>E | No | EVA | |
| rs33722333 | 96 | A>V | No | EVA | |
| rs3388614837 | 108 | P>S | No | EVA | |
| rs226664150 | 124 | S>P | No | EVA | |
| rs3388607098 | 150 | F>L | No | EVA | |
| rs3388607083 | 164 | A>S | No | EVA | |
| rs3388607083 | 164 | A>T | No | EVA | |
| rs3388619285 | 179 | Q>E | No | EVA | |
| rs27614974 | 191 | K>Q | No | EVA | |
| rs3388615873 | 204 | A>G | No | EVA | |
| rs27614973 | 206 | L>R | No | EVA | |
| rs3388614813 | 215 | D>E | No | EVA | |
| rs3388618715 | 244 | D>G | No | EVA | |
| rs256751392 | 255 | R>K | No | EVA | |
| rs3388613233 | 262 | F>V | No | EVA | |
| rs3388617038 | 262 | F>Y | No | EVA | |
| rs3388615912 | 287 | Q>H | No | EVA | |
| rs27614962 | 291 | T>I | No | EVA | |
| rs3388618658 | 292 | V>M | No | EVA | |
| rs3388614855 | 301 | E>K | No | EVA | |
| rs3388619224 | 322 | K>T | No | EVA | |
| rs3388618655 | 323 | V>A | No | EVA | |
| rs1133984175 | 350 | G>S | No | EVA | |
| rs243087656 | 354 | N>D | No | EVA | |
| rs3388614981 | 364 | L>Q | No | EVA | |
| rs3388617005 | 373 | R>* | No | EVA | |
| rs3388600517 | 378 | N>I | No | EVA | |
| rs3388609865 | 379 | S>F | No | EVA | |
| rs3388600463 | 384 | G>R | No | EVA | |
| rs3388617882 | 394 | D>G | No | EVA | |
| rs3388611671 | 408 | V>M | No | EVA | |
| rs1134772445 | 428 | V>I | No | EVA | |
| rs3388607099 | 432 | W>* | No | EVA | |
| rs27614960 | 444 | S>T | No | EVA | |
| rs27614959 | 463 | T>S | No | EVA | |
| rs3388614784 | 476 | R>* | No | EVA | |
| rs3388612842 | 479 | R>M | No | EVA | |
| rs259148918 | 482 | D>H | No | EVA | |
| rs864266671 | 482 | D>V | No | EVA | |
| rs229376617 | 529 | L>V | No | EVA | |
| rs27614958 | 534 | S>N | No | EVA | |
| rs3388607087 | 536 | D>V | No | EVA | |
| rs258159462 | 537 | R>H | No | EVA | |
| rs3388611634 | 570 | D>N | No | EVA | |
| rs3388613284 | 586 | F>L | No | EVA | |
| rs27614956 | 589 | N>S | No | EVA | |
| rs3388618686 | 596 | D>N | No | EVA | |
| rs235627573 | 603 | I>T | No | EVA | |
| rs236139535 | 623 | P>L | No | EVA | |
| rs252614435 | 630 | E>K | No | EVA | |
| rs27614953 | 633 | R>K | No | EVA | |
| rs3388615861 | 635 | N>S | No | EVA | |
| rs3388613760 | 647 | L>Q | No | EVA | |
| rs264944577 | 654 | T>P | No | EVA | |
| rs256509694 | 679 | S>T | No | EVA | |
| rs3388615053 | 712 | S>I | No | EVA | |
| rs3388611592 | 787 | S>L | No | EVA | |
| rs1134436378 | 795 | H>Y | No | EVA | |
| rs3388615021 | 797 | R>W | No | EVA | |
| rs3388615859 | 801 | D>V | No | EVA |
No associated diseases with Q08EC4
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of protein tyrosine kinase activity | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. |
| positive regulation of substrate adhesion-dependent cell spreading | Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NQ75 | CASS4 | Cas scaffolding protein family member 4 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRGTSIREGA | PKTLLARALY | DNHADCSDEL | AFSRGDILTI | VEQNVPESEG | WWRCLLHGRQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLAPANRLQV | LRETPADRPC | PLLPRGPDTD | LTSSGAPYQV | QDLISPPPQG | PVYEPMRSWV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGPSPATAQV | YELPESPSSA | RIICEKTLSF | PKQALSVLPR | PTRASLPTLP | SQVYDVPVQR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QGFSTLERLE | KQQFYDIPTS | SQKALLHSST | SQGRDVTLAP | TMAFRQGGGY | NPLSSPQKSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIHDTPVLLE | KADVRNVSMT | SFTKDSGSRA | IPGSSAVHTG | AVALSPQLGN | TVQRKNSLPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPTYAFPTSR | DPLPSDAGGS | YKVPSRFLIP | RVEQQNTMPN | IYDTPKAMQG | VSHNAPKAMQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVSLAGKELE | RGREAPENSP | WISGQTSFLS | PDSDRLSVAS | SDSRASVVSS | CSSISMDSSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSSSEDSVKE | LWMDVDFAKE | TAVSLQHKVA | SSAAGLLLFV | SRTWRFKDSL | ETNIHRIRRA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADHVEESVRE | FLDFAQGVGG | TACNLTDSYL | QARIRDQLQT | ISSSYQTLLD | AKGSLDRCNW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLEVLVTDKV | QNSLDDLERF | VATARIVPED | VKRFTSIVIA | NGKLLFKQNC | EKGEMDLKCE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RCIRPPQRET | ESYQESSPFD | RQPTTEHSFE | LARKNRVNVC | WQQSPNLQEK | GKPTMEGKSN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RNPDFHGMSP | PPLTSPSPSG | QNTERKIHLS | KHSRLYFGAL | FKAISVFASS | LSNGQPPEVF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITQSKLVITV | GQKLVDTLCS | ETQEKDERNE | ILCGSSHLCG | LLKDLALATK | SAVIQYPSPS |
| 790 | 800 | ||||
| ALSLLQSEVE | RLEHHSRKFR | DTLE |