Q08B31
PR
Gene name |
pi4k2a |
Protein name |
Phosphatidylinositol 4-kinase type 2-alpha |
Names |
Phosphatidylinositol 4-kinase type II-alpha |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:100158362 |
EC number |
2.7.1.67: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08B31
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08B31-F1 | Predicted | AlphaFoldDB |
No variants for Q08B31
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q08B31 | |||||
No associated diseases with Q08B31
1 regional properties for Q08B31
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 115 - 443 | IPR000403 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.67 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| growing cell tip | The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol 4-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). |
| AP-3 adaptor complex binding | Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDETSPLVSP | DRDQTEYSYQ | SQCSPGATVP | LSPNGRFSAL | PGVVVRIPGT | ATSCGSAASG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSPPGSPCDQ | ERQPLLERSQ | TRAAAAQAER | EMNKFPDDPA | FAEVVKKAEK | AIMRDILPER |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISQGSSGSYF | VKDEQGEIIA | VFKPKNEEPY | GQLNPKWTKW | LQKLCCPCCF | GRDCLVLNQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLSEAGASLV | DQKLDLNIVP | RTKVVFLASE | TFNYSAIDRV | KSRGKRLALE | KVPKVGQRFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIGLPPKVGS | FQIFVKSYKD | ADYWLRRFEA | DPLPENTNRQ | LQLQFERLVV | LDYIIRNTDR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNDNWLIKYD | CPMDSASARD | DWVMVKEPVI | KIAAIDNGLA | FPLKHPDSWR | AYPFYWAWLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAKIQFSQEI | KDLILPKISD | PNFVKDLEED | LYELFKKDQG | FDRGQFRKQI | AVMRGQILNL |
| 430 | 440 | 450 | 460 | ||
| TQAMKDGKSP | LQLVQTPPVI | VETARSHQKS | TSESYTQSFQ | SRKPFFSWW |