Q08959
Gene name |
PGC1 (YPL206C) |
Protein name |
Phosphatidylglycerol phospholipase C |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL206C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08959
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08959-F1 | Predicted | AlphaFoldDB |
3 variants for Q08959
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-163322 | 92 | T>I | No | SGRP | |
| s16-163238 | 120 | V>A | No | SGRP | |
| s16-162750 | 283 | I>V | No | SGRP |
No associated diseases with Q08959
1 regional properties for Q08959
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycerophosphodiester phosphodiesterase domain | 2 - 251 | IPR030395 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylglycerol phospholipase C activity | Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate. |
| phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycerophospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
| phosphatidylglycerol catabolic process | The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVEIVGHRAF | KARYPENTLL | AFEKAYAAGA | DVIETDLQMT | SDGMVVVNHD | SDTGRMWDKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVIGESTWEE | VKRLRCKEDG | SLAMMTLKEI | LTWAVCHPGA | KLMLDIKFTN | EKIIMIKTFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMLEVKNDLK | FWQERITWGL | WLLDWYDFGI | ETGVLKDFKV | IVISLSLDIA | SQFVKRSLTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NDPHYKLFGI | SVHFVSSWTS | QFRLRLLPVL | MKNDIKVYLW | TVNKPIDFKY | LCELPIHGAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDDPIKARKL | CDGHTVAKKP | TAEKKFVAPS | LASVDGLRFH | AFIKVYNILC | TLLYSKWVHI |
| 310 | 320 | ||||
| KLCGWSIAYV | IFLFLRTIHF | L |