Q08945
PR
Gene name |
SSRP1 (FACT80) |
Protein name |
FACT complex subunit SSRP1 |
Names |
Chromatin-specific transcription elongation factor 80 kDa subunit, Facilitates chromatin transcription complex 80 kDa subunit, FACT 80 kDa subunit, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, hSSRP1, T160 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6749 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for Q08945
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4IFS | X-ray | 193 A | A | 196-430 | PDB |
| 5UMR | X-ray | 150 A | A | 1-100 | PDB |
| 5UMS | X-ray | 157 A | A | 174-437 | PDB |
| 5VWE | NMR | - | A | 551-617 | PDB |
| 6L1E | X-ray | 209 A | A | 196-430 | PDB |
| 6L1R | X-ray | 180 A | A | 1-100 | PDB |
| 6L34 | X-ray | 200 A | A | 548-615 | PDB |
| 6UPK | EM | 490 A | H | 1-640 | PDB |
| 6UPL | EM | 740 A | H | 1-640 | PDB |
| AF-Q08945-F1 | Predicted | AlphaFoldDB |
352 variants for Q08945
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA380579805 rs1318345420 |
2 | A>V | No |
ClinGen TOPMed |
|
|
CA380579778 rs1269134434 |
5 | L>M | No |
ClinGen TOPMed |
|
|
rs1590613578 CA380579754 |
7 | F>V | No |
ClinGen Ensembl |
|
|
rs542006597 CA6004814 RCV000889511 |
10 | V>I | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA6004813 rs373402679 |
11 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1483648908 CA380579697 |
12 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA380579674 rs1300772771 |
14 | V>A | No |
ClinGen gnomAD |
|
|
CA380579675 rs1300772771 |
14 | V>G | No |
ClinGen gnomAD |
|
|
rs776365210 CA6004812 |
14 | V>L | No |
ClinGen ExAC |
|
|
CA380579658 rs1190621524 |
16 | G>S | No |
ClinGen TOPMed |
|
|
CA222712505 rs370222629 |
18 | M>V | No |
ClinGen ESP TOPMed |
|
|
rs755268663 CA6004780 |
27 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs145267582 CA6004779 RCV000954719 |
27 | R>H | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 27 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1565055979 CA380579471 |
28 | Q>E | No |
ClinGen Ensembl |
|
| TCGA novel | 29 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004777 rs761572094 |
30 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1281326986 CA380579438 |
31 | I>V | No |
ClinGen gnomAD |
|
|
rs1476823767 CA380579360 |
37 | T>I | No |
ClinGen TOPMed |
|
|
rs1245681389 CA380579365 |
37 | T>S | No |
ClinGen TOPMed |
|
|
CA6004774 rs760119577 |
38 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1415111881 CA380579285 |
44 | Q>* | No |
ClinGen gnomAD |
|
|
CA222712332 rs993363792 |
46 | G>E | No |
ClinGen gnomAD |
|
|
CA380579248 rs1295923776 |
48 | L>V | No |
ClinGen gnomAD |
|
|
CA6004773 rs775505662 |
49 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380579212 rs1408328078 |
51 | G>V | No |
ClinGen gnomAD |
|
|
rs1412294319 CA380579193 |
54 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs759396902 CA6004771 |
55 | R>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 57 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004769 rs771028574 |
60 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1458046004 CA380579138 |
60 | H>Y | No |
ClinGen TOPMed |
|
|
rs1387009168 CA380579110 |
62 | L>F | No |
ClinGen TOPMed |
|
|
rs1330650150 CA380579061 |
66 | T>I | No |
ClinGen TOPMed |
|
| TCGA novel | 67 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 77 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004764 rs781662202 |
79 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755536119 CA6004763 |
80 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs948110621 CA222709041 |
81 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 83 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004741 rs541213567 |
85 | L>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs755775968 CA6004739 |
87 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1424056391 CA380578375 |
88 | F>C | No |
ClinGen TOPMed |
|
|
rs1590611037 CA380578373 |
88 | F>L | No |
ClinGen Ensembl |
|
|
rs1424056391 CA380578377 |
88 | F>Y | No |
ClinGen TOPMed |
|
|
rs1469559178 CA380578369 |
89 | F>C | No |
ClinGen TOPMed |
|
|
CA380578363 rs1174735311 |
90 | K>E | No |
ClinGen TOPMed |
|
|
CA380578360 rs1456549503 |
90 | K>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA6004737 rs767096415 |
94 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377522214 CA6004736 |
94 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA222709026 rs377522214 |
94 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs751485584 CA6004735 |
95 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA380578322 rs1217301314 |
96 | E>G | No |
ClinGen gnomAD |
|
|
CA6004733 rs762803298 |
97 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs772938006 CA6004732 |
99 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373066245 CA6004730 |
101 | D>E | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 103 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1174360283 CA380578212 |
111 | T>I | No |
ClinGen gnomAD |
|
|
rs776062951 CA6004726 |
112 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA222709002 rs772515675 |
113 | K>R | No |
ClinGen ExAC |
|
|
CA6004725 rs772515675 |
113 | K>T | No |
ClinGen ExAC |
|
|
rs746225913 CA6004724 |
115 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779189385 CA6004723 |
115 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004697 rs144234860 |
117 | Q>E | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1487086828 CA380578124 |
123 | I>M | No |
ClinGen gnomAD |
|
|
rs1335943286 CA380578130 |
123 | I>V | No |
ClinGen TOPMed |
|
|
rs779469892 CA6004696 |
125 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1215873317 CA380578116 |
125 | D>H | No |
ClinGen gnomAD |
|
|
CA380578117 rs1215873317 |
125 | D>N | No |
ClinGen gnomAD |
|
|
rs369408799 CA6004694 |
127 | P>L | No |
ClinGen ESP ExAC TOPMed |
|
|
rs143017576 CA6004695 |
127 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1306551051 CA380578074 |
131 | I>L | No |
ClinGen TOPMed |
|
|
CA6004693 rs778921185 |
133 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1295464703 CA380578046 |
135 | N>S | No |
ClinGen gnomAD |
|
|
CA222708946 rs944302065 |
137 | S>C | No |
ClinGen Ensembl |
|
|
rs1360118061 CA380578036 |
137 | S>P | No |
ClinGen gnomAD |
|
|
rs1224850792 CA380578022 |
139 | C>R | No |
ClinGen TOPMed |
|
|
rs764280218 CA6004690 |
148 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA380577957 rs1162541497 |
149 | E>K | No |
ClinGen gnomAD |
|
|
rs1474827895 CA380577939 |
151 | H>Y | No |
ClinGen gnomAD |
|
|
rs201361828 CA6004688 |
153 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004685 rs201778138 |
156 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1590610263 CA380577893 |
157 | E>G | No |
ClinGen Ensembl |
|
|
rs1212563745 CA380577844 |
164 | R>C | No |
ClinGen gnomAD |
|
|
CA222708943 rs113062066 |
166 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs145791089 CA6004682 |
167 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1403813270 CA380577774 |
169 | P>H | No |
ClinGen TOPMed |
|
|
rs373177172 CA222708942 |
170 | T>S | No |
ClinGen ESP |
|
|
rs1296513761 CA380577714 |
173 | D>E | No |
ClinGen gnomAD |
|
|
rs768388628 CA6004681 |
173 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1360716967 CA380577689 |
175 | V>G | No |
ClinGen TOPMed |
|
|
CA222708941 rs967899383 |
176 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA380577600 rs1463381917 |
180 | A>T | No |
ClinGen gnomAD |
|
| TCGA novel | 180 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1163117498 CA380577515 |
186 | L>S | No |
ClinGen gnomAD |
|
|
rs765647715 CA6004664 |
189 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs1343983273 CA380577449 |
191 | V>I | No |
ClinGen TOPMed |
|
|
rs1253440528 CA380577391 |
195 | T>M | No |
ClinGen Ensembl |
|
| TCGA novel | 195 | T>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1197910336 CA380577345 |
199 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs140679224 CA6004660 |
201 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA222708930 rs368418155 COSM3791594 |
203 | R>W | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ESP TOPMed gnomAD |
|
rs72921999 CA222708929 |
204 | E>A | No |
ClinGen 1000Genomes gnomAD |
|
| TCGA novel | 212 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380577156 rs2230650 |
214 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs755802562 CA6004655 |
221 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004656 rs755802562 |
221 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755802562 CA380577064 |
221 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA222708928 rs768436 VAR_052495 |
225 | L>V | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs1434924407 CA380577007 |
226 | H>Y | No |
ClinGen gnomAD |
|
|
CA380576981 COSM1354756 rs1590609910 |
228 | K>E | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA380576948 rs1156302339 |
232 | Y>C | No |
ClinGen gnomAD |
|
|
CA380576890 rs1422397696 |
241 | R>C | No |
ClinGen gnomAD |
|
|
CA6004649 rs758573318 |
241 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs750902126 CA6004648 |
246 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1486772599 CA380576855 |
247 | H>N | No |
ClinGen gnomAD |
|
|
rs1354229678 CA380576783 |
256 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1166286583 CA380576106 |
269 | R>C | No |
ClinGen gnomAD |
|
|
CA6004620 rs761767957 |
269 | R>H | Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA222708909 rs112090839 |
271 | H>L | No |
ClinGen Ensembl |
|
|
rs1460866160 CA380576029 |
275 | L>V | No |
ClinGen TOPMed |
|
|
rs768440204 CA6004618 |
278 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA380575926 rs1478842710 |
282 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA380575914 rs1247050110 |
283 | I>V | No |
ClinGen gnomAD |
|
|
rs200509142 CA6004616 |
284 | S>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 287 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380575846 rs1214280927 |
288 | N>S | No |
ClinGen gnomAD |
|
|
rs1336619542 COSM3791593 CA380575824 |
289 | M>I | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1590609581 CA380575834 |
289 | M>V | No |
ClinGen Ensembl |
|
|
rs754313242 CA6004611 |
291 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs764822163 CA6004612 |
291 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA6004600 rs765842738 |
294 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs973761122 CA222708901 |
295 | E>D | No |
ClinGen Ensembl |
|
|
CA6004599 rs775473221 |
295 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1303459920 CA380575668 |
297 | R>C | No |
ClinGen gnomAD |
|
|
COSM219151 rs772025027 CA6004598 |
301 | R>W | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA6004597 rs746040644 |
304 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 305 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA222708899 rs201642712 |
305 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA380575395 rs1366428896 |
316 | R>P | No |
ClinGen Ensembl |
|
|
rs770977879 CA6004595 |
316 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778334664 CA6004593 |
318 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA222708898 rs369372594 |
320 | A>T | No |
ClinGen Ensembl |
|
|
rs1417468897 CA380575330 |
321 | L>R | No |
ClinGen gnomAD |
|
|
COSM1354755 rs748483435 CA6004591 |
324 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA380575293 rs1590609312 COSM928573 |
324 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA6004590 rs755354855 |
329 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755354855 CA6004589 |
329 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA222708896 rs972561180 |
331 | N>D | No |
ClinGen TOPMed |
|
|
CA380575205 rs750030043 |
331 | N>I | No |
ClinGen ExAC gnomAD |
|
|
rs750030043 CA6004588 |
331 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA380575008 rs1184277632 |
340 | C>G | No |
ClinGen TOPMed |
|
|
CA222708864 rs975587252 |
342 | T>I | No |
ClinGen gnomAD |
|
|
rs1460691803 CA380574948 |
344 | S>C | No |
ClinGen gnomAD |
|
|
rs1418337949 CA380574937 |
345 | Y>C | No |
ClinGen gnomAD |
|
| TCGA novel | 347 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1426338503 CA380574879 |
349 | S>* | No |
ClinGen gnomAD |
|
|
CA380574831 rs1195530879 |
354 | P>A | No |
ClinGen TOPMed |
|
|
CA380574824 rs1186583601 |
354 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1416365006 CA380574810 |
356 | E>K | No |
ClinGen Ensembl |
|
|
CA380574796 rs1565053805 |
357 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA222708863 rs965754863 |
362 | V>I | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 367 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1031692895 COSM1354754 CA222708862 |
370 | R>C | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs763084886 CA380574594 |
371 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380574545 rs1307122164 |
375 | S>P | No |
ClinGen gnomAD |
|
| TCGA novel | 378 | N>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004556 rs761882041 |
395 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs369695760 CA222708860 |
398 | G>S | No |
ClinGen Ensembl |
|
|
rs1323754152 CA380574233 |
399 | T>A | No |
ClinGen gnomAD |
|
|
CA380574220 rs1295774767 |
400 | Q>P | No |
ClinGen TOPMed |
|
|
rs1590608691 CA380574140 |
405 | S>R | No |
ClinGen Ensembl |
|
| TCGA novel | 412 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs377487337 CA6004536 |
413 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA380574029 rs1184838198 |
414 | L>R | No |
ClinGen gnomAD |
|
|
CA222708776 rs924483026 |
414 | L>V | No |
ClinGen TOPMed |
|
| TCGA novel | 415 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 418 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1356018028 CA380574003 |
418 | V>L | No |
ClinGen TOPMed |
|
|
CA6004534 rs772260998 |
419 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004532 rs777555591 |
420 | A>V | Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1236759465 CA380573982 |
421 | K>R | No |
ClinGen gnomAD |
|
|
CA380573978 rs1335137330 |
422 | K>E | No |
ClinGen gnomAD |
|
|
CA6004530 rs747635733 |
424 | N>T | No |
ClinGen ExAC gnomAD |
|
|
rs1311899256 CA380573931 |
428 | R>Q | No |
ClinGen gnomAD |
|
|
CA380573926 rs754541795 |
429 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs754541795 CA6004528 |
429 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1053028904 CA222708773 |
431 | K>R | No |
ClinGen Ensembl |
|
|
CA6004509 rs767982791 |
433 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1473893427 CA380573865 |
436 | P>R | No |
ClinGen gnomAD |
|
| TCGA novel | 440 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1192486332 CA380573827 |
441 | Y>C | No |
ClinGen gnomAD |
|
|
CA6004507 rs779838351 |
442 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380573818 rs779838351 |
442 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380573752 rs1310128504 |
451 | A>V | No |
ClinGen TOPMed |
|
|
CA6004505 rs745630542 |
454 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
VAR_052496 rs11540304 CA222708727 |
458 | E>Q | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs1317468322 CA380573629 |
468 | N>S | No |
ClinGen TOPMed |
|
|
rs1268061948 CA380573612 |
470 | S>T | No |
ClinGen gnomAD |
|
|
CA6004500 rs756136882 |
472 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 475 | G>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs963929589 CA222708725 |
475 | G>E | No |
ClinGen Ensembl |
|
|
CA380573537 rs1590607069 |
479 | D>E | No |
ClinGen Ensembl |
|
|
CA380573510 rs1479025098 |
483 | N>T | No |
ClinGen TOPMed |
|
|
CA380573504 rs1565052771 |
484 | P>A | No |
ClinGen Ensembl |
|
|
rs1046160960 CA222708713 |
485 | G>D | No |
ClinGen TOPMed |
|
|
rs1046160960 CA380573495 |
485 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| rs1424303401 | 493 | E>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004459 rs781573004 |
495 | F>V | No |
ClinGen ExAC gnomAD |
|
|
rs768189674 CA222708523 |
498 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004456 COSM1354752 rs780681897 |
498 | N>S | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1472805398 CA380573385 |
499 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1253468389 CA380573373 |
501 | A>T | No |
ClinGen gnomAD |
|
|
CA380573368 rs1433260068 |
501 | A>V | No |
ClinGen TOPMed |
|
|
rs1185390973 CA380573348 |
504 | S>F | No |
ClinGen gnomAD |
|
|
rs943407423 CA222708522 |
508 | G>A | No |
ClinGen TOPMed |
|
|
CA6004452 rs765586387 |
510 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA380573293 rs752279750 |
512 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004450 rs752279750 |
512 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748785342 CA6004451 |
512 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 513 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767216231 CA6004449 |
516 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs374350120 CA6004447 |
517 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372798116 CA6004448 |
517 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6004446 rs770461992 |
525 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1345455659 CA380573188 |
526 | A>V | No |
ClinGen TOPMed |
|
|
rs1242139679 CA380573174 |
527 | K>N | No |
ClinGen TOPMed |
|
| TCGA novel | 528 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004444 rs370685904 |
529 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs769568719 CA6004443 |
529 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs747956444 CA6004442 |
530 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA380573132 rs1230156988 |
531 | S>N | No |
ClinGen Ensembl |
|
|
rs769046358 CA6004440 |
532 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380573118 rs988338838 |
532 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs988338838 CA222708520 |
532 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
rs747051359 CA6004439 |
533 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA6004436 rs758427850 |
536 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs746000479 CA380573020 |
538 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs746000479 CA6004415 |
538 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1341783150 CA380572987 |
541 | G>R | No |
ClinGen gnomAD |
|
| TCGA novel | 541 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1298405270 CA380572980 |
541 | G>V | No |
ClinGen gnomAD |
|
|
CA6004412 rs144558178 |
545 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1409920554 CA380572913 |
548 | K>Q | No |
ClinGen TOPMed |
|
|
rs1385961996 CA380572910 |
548 | K>R | No |
ClinGen gnomAD |
|
|
rs1368075415 CA380572894 |
550 | P>T | No |
ClinGen gnomAD |
|
|
CA380572880 rs1295107443 |
551 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs778065936 CA6004411 |
552 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA222708481 rs898859607 |
554 | Y>N | No |
ClinGen TOPMed |
|
|
rs370156740 CA6004408 |
559 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757908662 CA6004407 |
561 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs1198818327 CA380572769 |
562 | R>* | No |
ClinGen gnomAD |
|
|
CA380572751 rs1369844302 |
564 | K>E | No |
ClinGen TOPMed |
|
|
rs749945399 CA6004406 |
564 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1269887973 CA380572743 |
564 | K>N | No |
ClinGen gnomAD |
|
|
rs1273390577 CA380572711 |
567 | S>L | No |
ClinGen TOPMed |
|
|
rs765187747 CA6004405 |
569 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA6004404 COSM78579 rs761799650 |
575 | T>M | ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 576 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1284198822 CA380572565 |
580 | K>T | No |
ClinGen TOPMed |
|
|
rs1041947885 CA222708480 |
583 | E>D | No |
ClinGen Ensembl |
|
|
rs149785307 CA380572501 |
584 | I>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149785307 CA6004402 |
584 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6004400 rs775776663 |
592 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1308287795 CA380572291 |
594 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 595 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004383 rs756839016 |
598 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA222708465 rs879145494 |
598 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1369132649 CA380572130 |
600 | A>P | No |
ClinGen TOPMed |
|
|
rs1314036651 CA380572111 |
602 | D>N | No |
ClinGen TOPMed |
|
|
rs764192967 CA6004381 |
603 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA6004379 rs752475213 |
604 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs201685642 CA6004377 |
606 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 608 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6004375 rs770934067 |
610 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA380571973 rs1188248956 |
611 | M>R | No |
ClinGen TOPMed gnomAD |
|
|
COSM1676028 CA380571976 rs1188248956 |
611 | M>T | prostate [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA380571959 rs1444209480 |
612 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
CA380571864 rs1206712079 |
617 | G>A | No |
ClinGen gnomAD |
|
|
CA6004373 rs773699958 |
618 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004371 rs748477169 |
620 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA380571781 rs1211431710 |
623 | K>E | No |
ClinGen TOPMed |
|
|
rs985933102 CA222708408 |
626 | K>R | No |
ClinGen TOPMed |
|
|
CA6004349 rs747472825 |
627 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1407284220 CA380571583 |
628 | K>E | No |
ClinGen gnomAD |
|
|
rs199803004 CA222708407 |
628 | K>R | No |
ClinGen 1000Genomes |
|
|
CA380571534 COSM928565 rs1235744456 |
630 | K>N | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA380571518 rs368768420 CA6004347 |
631 | K>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs748980756 CA6004344 |
633 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1590603449 CA380571459 |
635 | V>A | No |
ClinGen Ensembl |
|
|
rs1351074537 CA380571446 |
636 | K>T | No |
ClinGen gnomAD |
|
|
rs1328136834 CA380571434 |
637 | M>V | No |
ClinGen gnomAD |
|
|
CA6004342 rs777370098 |
641 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004341 rs542109626 |
642 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs191760277 CA380571310 |
643 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs754720301 CA6004338 |
643 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs191760277 CA6004339 |
643 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs191760277 CA222708404 |
643 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA380571288 rs751423235 |
644 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004337 rs751423235 |
644 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769170471 CA6004336 |
645 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380571278 rs769170471 |
645 | R>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA222708402 rs1035884861 |
646 | G>C | No |
ClinGen Ensembl |
|
|
rs376694903 CA222708401 |
646 | G>V | No |
ClinGen ESP TOPMed |
|
|
CA6004335 rs750663512 |
647 | S>* | No |
ClinGen ExAC gnomAD |
|
|
CA6004334 rs750663512 |
647 | S>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 650 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380571171 rs1217958155 |
651 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1348619573 CA380571137 |
653 | S>L | No |
ClinGen Ensembl |
|
|
rs776998829 CA6004330 |
655 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA380571077 rs1368760613 |
657 | S>I | No |
ClinGen TOPMed |
|
|
CA380571053 rs1590603236 |
658 | E>D | No |
ClinGen Ensembl |
|
|
CA6004328 rs760925841 |
658 | E>K | No |
ClinGen ExAC |
|
|
rs775957545 CA6004327 |
659 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1277187239 CA380571008 |
661 | K>R | No |
ClinGen TOPMed |
|
|
CA380570995 rs1318804168 |
662 | S>I | No |
ClinGen TOPMed |
|
| TCGA novel | 663 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 663 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs748893034 CA6004325 |
664 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004326 rs772587723 |
664 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA380570934 rs1463672036 |
666 | V>M | No |
ClinGen TOPMed |
|
|
CA6004324 rs773005161 |
667 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs1172874050 CA380570905 |
668 | S>R | No |
ClinGen gnomAD |
|
|
rs1427622260 CA380570855 |
670 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
rs138466158 CA222708400 |
670 | E>Q | No |
ClinGen ESP gnomAD |
|
|
rs867945111 CA222708399 |
672 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1477582186 CA380570822 |
672 | S>P | No |
ClinGen TOPMed |
|
|
CA380570809 rs1483208516 |
673 | S>L | No |
ClinGen gnomAD |
|
|
CA6004319 rs746976175 |
675 | E>D | No |
ClinGen ExAC |
|
|
CA6004320 rs754988038 |
675 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA222708398 rs1048643321 |
676 | N>K | No |
ClinGen gnomAD |
|
|
rs1419131854 CA380570711 |
681 | K>R | No |
ClinGen TOPMed |
|
|
CA380570697 rs1385847534 |
682 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1462635301 CA380570669 |
685 | S>G | No |
ClinGen TOPMed |
|
|
rs758199473 CA6004314 |
685 | S>R | No |
ClinGen ExAC TOPMed |
|
|
CA380570663 rs1288161846 |
686 | E>K | No |
ClinGen gnomAD |
|
|
CA222708372 rs749745883 |
688 | S>Y | No |
ClinGen Ensembl |
|
|
CA6004297 rs779973680 |
689 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA380570556 rs142261788 |
692 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs142261788 CA6004295 |
692 | E>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs376345094 CA6004294 |
693 | L>V | No |
ClinGen ESP ExAC TOPMed |
|
|
CA380570503 rs1329631918 |
697 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA380570499 rs757540521 |
697 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6004292 rs757540521 |
697 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1329631918 CA380570505 |
697 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA222708371 rs865808282 |
698 | P>L | No |
ClinGen Ensembl |
|
|
CA6004291 rs372058811 |
698 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 699 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 699 | S>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380570484 rs1184960500 |
699 | S>T | No |
ClinGen gnomAD |
|
|
rs1278826058 CA380570450 |
702 | D>G | No |
ClinGen gnomAD |
|
|
CA380570424 rs1272356295 |
704 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1263859557 CA380570389 COSM928564 |
708 | D>N | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
No associated diseases with Q08945
4 regional properties for Q08945
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 546 - 616 | IPR009071 |
| domain | Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain | 338 - 428 | IPR013719 |
| domain | SSRP1, dimerization domain | 106 - 170 | IPR024954 |
| domain | FACT complex subunit SSRP1/POB3, N-terminal PH domain | 6 - 97 | IPR035417 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| FACT complex | A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| nucleosome disassembly | The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| regulation of chromatin organization | Any process that modulates the frequency, rate or extent of chromatin organization. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04636 | POB3 | FACT complex subunit POB3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAETLEFNDV | YQEVKGSMND | GRLRLSRQGI | IFKNSKTGKV | DNIQAGELTE | GIWRRVALGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLKLLTKNGH | VYKYDGFRES | EFEKLSDFFK | THYRLELMEK | DLCVKGWNWG | TVKFGGQLLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FDIGDQPVFE | IPLSNVSQCT | TGKNEVTLEF | HQNDDAEVSL | MEVRFYVPPT | QEDGVDPVEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FAQNVLSKAD | VIQATGDAIC | IFRELQCLTP | RGRYDIRIYP | TFLHLHGKTF | DYKIPYTTVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLFLLPHKDQ | RQMFFVISLD | PPIKQGQTRY | HFLILLFSKD | EDISLTLNMN | EEEVEKRFEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLTKNMSGSL | YEMVSRVMKA | LVNRKITVPG | NFQGHSGAQC | ITCSYKASSG | LLYPLERGFI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVHKPPVHIR | FDEISFVNFA | RGTTTTRSFD | FEIETKQGTQ | YTFSSIEREE | YGKLFDFVNA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KKLNIKNRGL | KEGMNPSYDE | YADSDEDQHD | AYLERMKEEG | KIREENANDS | SDDSGEETDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SFNPGEEEED | VAEEFDSNAS | ASSSSNEGDS | DRDEKKRKQL | KKAKMAKDRK | SRKKPVEVKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GKDPNAPKRP | MSAYMLWLNA | SREKIKSDHP | GISITDLSKK | AGEIWKGMSK | EKKEEWDRKA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EDARRDYEKA | MKEYEGGRGE | SSKRDKSKKK | KKVKVKMEKK | STPSRGSSSK | SSSRQLSESF |
| 670 | 680 | 690 | 700 | ||
| KSKEFVSSDE | SSSGENKSKK | KRRRSEDSEE | EELASTPPSS | EDSASGSDE |