Q08749

PR
Gene name
TIM18 (YOR297C)
Protein name
Mitochondrial import inner membrane translocase subunit TIM18
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR297C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q08749

Entry ID Method Resolution Chain Position Source
6LO8 EM 383 A D 1-192 PDB
AF-Q08749-F1 Predicted AlphaFoldDB

6 variants for Q08749

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-875292 10 V>A No SGRP
s15-875278 15 T>A No SGRP
s15-875003 106 I>M No SGRP
s15-874981 114 L>I No SGRP
s15-874938 128 S>T No SGRP
s15-874885 146 A>S No SGRP

No associated diseases with Q08749

No regional properties for Q08749

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q08749

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
TIM22 mitochondrial import inner membrane insertion complex A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
protein insertion into mitochondrial inner membrane The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.
protein transmembrane transport The process in which a protein is transported across a membrane.
response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VCI5 SdhD Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Drosophila melanogaster (Fruit fly) PR
O62215 sdhd-1 Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Caenorhabditis elegans PR
10 20 30 40 50 60
MLLFPGLKPV LNASTVIVNP VRAVFPGLVL STKRSFYSIN RLNAENKIND IANTSKEASS
70 80 90 100 110 120
SVQMFKPPEF SQFKDSYQKD YERIAKYTLI PLTMVPFYAS FTGGVINPLL DASLSSIFLI
130 140 150 160 170 180
YLQYGFTSCI IDYIPKEKYP RWHKLALYCL YGGSMLSLYG IYELETKNNG FVDLVKKLWN
190
ENDDHLYIFG RN