Q08287
Gene name |
NOP8 (YOL144W) |
Protein name |
60S ribosome subunit biogenesis protein NOP8 |
Names |
Nucleolar protein 8 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL144W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08287
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08287-F1 | Predicted | AlphaFoldDB |
6 variants for Q08287
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-53262 | 56 | E>K | No | SGRP | |
| s15-53356 | 87 | S>T | No | SGRP | |
| s15-53706 | 204 | S>G | No | SGRP | |
| s15-54003 | 303 | K>E | No | SGRP | |
| s15-54060 | 322 | G>S | No | SGRP | |
| s15-54184 | 363 | Q>L | No | SGRP |
No associated diseases with Q08287
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSVIQKRIF | VGNIFHNADD | CYSELLDRFG | KFGDCQDFQF | EKHNHFAFID | IRFNDEADFN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLRKSFNNVK | FKGNILKVDE | AKPNWESTWA | VQHAKDLKED | IILNAKMKKK | NWQHYKKMEN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAKSWKDHKE | VIAGRMREAP | RKRSQLRNIT | FRINVNGSLK | VYKCYKTKLW | GYERNKELND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVYKFTNNFW | KNGYNHIVDR | LDYSRAVKTV | RFKNGLKQLT | VSKDENVCSG | EMDSDENMSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEKEKNNVIL | NDLLKDFDFD | KPMTLNDSDE | ELLTEQRKGE | EEEEEEEEKE | VNAPEYENVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KTKDQSTLPQ | EKPEERKEQD | EGDGQEDNEF | IPTFTKEIGQ | GTISNTETLR | NLFNPNEAEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSQFKLIEDS | DNDIDHAKDV | DVNQLEEEVS | KSSDTLGLTS | APVPHVSRDK | DNKNFLFFPH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LQSPFLVGQT | QLSKVRAPGR | ETMLSNWDEE | FWANRGNWTR | DMRRKMKDAL | KHRKRKQSKS |
| GLLL |