Q08225
Gene name |
YOL057W (O1232) |
Protein name |
Probable dipeptidyl peptidase 3 |
Names |
Dipeptidyl aminopeptidase III, Dipeptidyl arylamidase III, Dipeptidyl peptidase III, DPP III |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL057W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q08225
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3CSK | X-ray | 195 A | A | 1-711 | PDB |
| AF-Q08225-F1 | Predicted | AlphaFoldDB |
15 variants for Q08225
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-220899 | 45 | R>K | No | SGRP | |
| s15-220973 | 70 | N>D | No | SGRP | |
| s15-220985 | 74 | P>S | No | SGRP | |
| s15-221061 | 99 | G>A | No | SGRP | |
| s15-221111 | 116 | K>E | No | SGRP | |
| s15-221191 | 142 | N>K | No | SGRP | |
| s15-221205 | 147 | S>F | No | SGRP | |
| s15-221381 | 206 | A>S | No | SGRP | |
| s15-221474 | 237 | E>K | No | SGRP | |
| s15-221561 | 266 | L>I | No | SGRP | |
| s15-221840 | 359 | A>S | No | SGRP | |
| s15-222128 | 455 | V>I | No | SGRP | |
| s15-222372 | 536 | I>T | No | SGRP | |
| s15-222521 | 586 | M>V | No | SGRP | |
| s15-222851 | 696 | D>N | No | SGRP |
No associated diseases with Q08225
No regional properties for Q08225
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q08225 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. |
| dipeptidyl-peptidase activity | Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. |
| metal ion binding | Binding to a metal ion. |
| metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHFFADHDA | PLSMLSVKTE | YFPQLTDKEQ | KYAHFMSKAS | HAGSRVVMRQ | VSHESEPIFD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LILAIHSKLN | GKYPEDDITQ | KQQTGLYLEY | VSQFLSNLGN | FKSFGDTKFI | PRCEVKFFKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLELAKINPC | SSPLTLSPVD | VNHEFTSHHL | FSTINELIDI | GIYHVEEKAA | LLGFPSQGYT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAYYLGLPVT | PEDMALLKEQ | LFAELAILPE | NTRINKVGEN | SFQIWVASEN | VKNQITETYP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGQITLSNAV | TKVEFIFGDH | SREMRLVASY | LKEAQKFAAN | DTQKAMLQEY | INHFVTGSSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AHKEAQKLWV | KDISPVIETN | IGFIETYREP | SGIIGEFESL | VAIQNKERTA | KFSSLVNNAE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EFISLLPWSK | DYEKPIFNPP | DFTSLEVLTF | TGSGIPAGIN | IPNYDDVRLK | IGFKNVSLGN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILSAAAKSSS | KHPPSFISQE | DRPIFEKYQS | DSFEVQVGIH | ELLGHGSGKL | LTEFTDGFNF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DKENPPLGLD | GKPVSTYYKV | GETWGSKFGQ | LAGPFEECRA | EVIAMFLLTN | KKILDIFGFH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DVESQDKVIY | AGYLQMARAG | LLALEYWNPK | TGKWGQPHMQ | ARFSIMKTFM | KHSTDKNFLK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LEMNSTNDDF | AIKLDKSLIK | TAGHECVKDY | LKHLHVYKCS | GDVEQGSKYF | IDRSTVTPDL |
| 670 | 680 | 690 | 700 | 710 | |
| ASLRDIVLSK | RLPRRQFIQS | NSYIDDNNKV | TLKEYDETPQ | GMLQSFLDRE | L |