Q07DZ6

PR
Gene name
CFTR (ABCC7)
Protein name
Cystic fibrosis transmembrane conductance regulator
Names
CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel
Species
Ornithorhynchus anatinus (Duckbill platypus)
KEGG Pathway
oaa:100078764
EC number
5.6.1.6: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

622-721 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q07DZ6

Entry ID Method Resolution Chain Position Source
AF-Q07DZ6-F1 Predicted AlphaFoldDB

1 variants for Q07DZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs69689394 911 V>I No Ensembl

No associated diseases with Q07DZ6

9 regional properties for Q07DZ6

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 423 - 646 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1212 - 1445 IPR003439-2
domain AAA+ ATPase domain 450 - 623 IPR003593-1
domain AAA+ ATPase domain 1238 - 1420 IPR003593-2
domain ABC transporter type 1, transmembrane domain 82 - 349 IPR011527-1
domain ABC transporter type 1, transmembrane domain 865 - 1162 IPR011527-2
conserved_site ABC transporter-like, conserved site 548 - 562 IPR017871
domain CFTR regulator domain 639 - 850 IPR025837
domain Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 389 - 670 IPR047082

Functions

Description
EC Number 5.6.1.6 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Nucleus
  • The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane
  • In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia
  • In Sertoli cells, a processed product is detected in the nucleus
  • ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell surface The external part of the cell wall and/or plasma membrane.
chloride channel complex An ion channel complex through which chloride ions pass.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

14 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
chloride channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a chloride channel.
chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
Sec61 translocon complex binding Binding to a Sec61 translocon complex.

21 GO annotations of biological process

Name Definition
amelogenesis The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.
bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
chloride transmembrane transport The process in which chloride is transported across a membrane.
cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
positive regulation of cyclic nucleotide-gated ion channel activity Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity.
positive regulation of enamel mineralization Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.
positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis.
positive regulation of insulin secretion involved in cellular response to glucose stimulus Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of voltage-gated chloride channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity.
response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
transepithelial water transport The directed movement of water (H2O) from one side of an epithelium to the other.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRSPLERAN LFSKLFFSWT KPILKKGYRQ HLELSDIYQI PTADSADNLS EKLEREWDRE
70 80 90 100 110 120
LASKKNPKLI NALRRCFFWR FMFYGLLLYL GEVTKAVQPL LLGRIIASYD PDNAHERSIA
130 140 150 160 170 180
YYLGIGLCLL FIVRTLLLHP AVFGLHHIGM QMRIALFSLI YKKTLKLSSR VLDKISTGQL
190 200 210 220 230 240
VSLLSNNLNK FDEGLALAHF VWIAPLQVML LMGLLWDLLQ ASAFCGLAVL VVLVLFQAWL
250 260 270 280 290 300
GHRMMKYRDR RAGKINERLV ITAEIIENIQ SVKAYCWEEA MENMIESLRE TELKLTRKAA
310 320 330 340 350 360
YMRYFNSSAF FFSGFFVVFL SVLPSMLTKG IVLRKIFTTI SFCIVLRMAV TRQFPWAVQM
370 380 390 400 410 420
WYDSIGAIYK IQDFLQKEEY KTLEYNLTTT DVVMENVTAF WDEGFGELLV KAKQNDSSRK
430 440 450 460 470 480
VSSDDKNLIF SNISLLGPPV LKDISFKIEK GQLLAVAGST GAGKTSLLMM IMGELEPLEG
490 500 510 520 530 540
KIKHSGRISF SPQFSWIMPG TIKENIVFGV SFDEYRYRSV IKACQLEEEI SKFAEKDNTV
550 560 570 580 590 600
LGEGGITLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV LTEKEIFESC VCKLMANKTR
610 620 630 640 650 660
ILVTSKMEHL KKADKILILH EGSCYFYGAF SELQNLRPDF SSKLMGYDSF DQFSAERRNS
670 680 690 700 710 720
ILTETLRRFS LDGDAAGSWN ETKKQSFKQT GEFGERRKNS ILNPLNSIRK FSLVQKAPLQ
730 740 750 760 770 780
MNCIDETLDE PPERKLSLVP DSEPGEAILP RSNMLNPGPV LRARRRQSVL NLMTRPSIHQ
790 800 810 820 830 840
GSSLYKKGSA SARKMSVAPQ SNMSEMDIYS RRLSKDSGLE ISEEINEEDL KECFIDDIES
850 860 870 880 890 900
TTSVTTWNTY LRYMTIHKKL IFVLMMCLVI FLIEVAASLV GLCLFKDGAS RMNSTSNLNH
910 920 930 940 950 960
TSTLDWFAVI VTNTSTYYMF YIYVGVADTL LALGFLRGLP LVHSLISVSK ILHQKMLHSV
970 980 990 1000 1010 1020
LQAPMSTFNT LKTGSILNRF SKDMAILDDL LPLTIFDFIQ LLLIVIGAVT VVSALQPYIF
1030 1040 1050 1060 1070 1080
LASVPVVIAF VLLRAYFLRT SQQLKQLESE ARSPIFTHLI TSLKGLWTLR AFGRQTYFEA
1090 1100 1110 1120 1130 1140
LFHKALNLHT ANWFLYLSTL RWFQMRIEMV FVIFFILVTF ISILTTGDGE GKVGIVLTLA
1150 1160 1170 1180 1190 1200
MNIMGTLQWA VNASIDVDSL MRSVSRVFKF IDMPTEEHRP THPAKNKDIS GVLIIENQHV
1210 1220 1230 1240 1250 1260
KREKNWPSGG QMTVQDLTAK YLDGGPAILD NISFSISSGQ RVGLLGRTGS GKSTLLFAFL
1270 1280 1290 1300 1310 1320
RLLNTEGDIR IDGISWDAVP VQQWRKAFGV IPQKVFIFSG SFRKNLDPYG QWTDQELWKV
1330 1340 1350 1360 1370 1380
AEEVGLKSVI EQFPGQLDFV LIDGGYVLSH GHRQLMCLAR SVLSKAKILL LDEPSAHLDP
1390 1400 1410 1420 1430 1440
ITYQVIRKTL KQAFTNCTVI LSEHRIEAML ECQRFLVIEE NKVRQYESIQ KLLNEKSVFK
1450 1460 1470 1480
QAISHSDKMK LFPIHRRNSS KRLSRPKITA LQEETEEEVQ DTRL