Q07794

PR
Gene name
RTT109
Protein name
Histone acetyltransferase RTT109
Names
Regulator of Ty1 transposition protein 109
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLL002W
EC number
2.3.1.48: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-190 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for Q07794

Entry ID Method Resolution Chain Position Source
2RIM X-ray 220 A A 1-436 PDB
2ZFN X-ray 190 A A 1-436 PDB
3CZ7 X-ray 200 A PDB
3Q33 X-ray 280 A A 1-436 PDB
3Q35 X-ray 330 A A 1-436 PDB
3Q66 X-ray 270 A C 1-436 PDB
3Q68 X-ray 270 A C 1-436 PDB
3QM0 X-ray 310 A A 1-436 PDB
6F0Y NMR - B 419-433 PDB
6O22 Other - C 1-436 PDB
AF-Q07794-F1 Predicted AlphaFoldDB

10 variants for Q07794

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-146306 6 F>Y No SGRP
s12-146572 95 N>D No SGRP
s12-146587 100 V>I No SGRP
s12-146788 167 E>K No SGRP
s12-146795 169 P>L No SGRP
s12-146800 171 F>L No SGRP
s12-147004 239 Q>K No SGRP
s12-147059 257 R>K No SGRP
s12-147400 371 D>N No SGRP
s12-147584 432 A>V No SGRP

No associated diseases with Q07794

1 regional properties for Q07794

Type Name Position InterPro Accession
domain Ribosomal protein S10 domain 63 - 160 IPR027486

Functions

Description
EC Number 2.3.1.48 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
H3 histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histone H3.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
H3 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
histone acetyltransferase activity (H3-K14 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).
histone acetyltransferase activity (H3-K23 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23).
histone acetyltransferase activity (H3-K27 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27).
histone acetyltransferase activity (H3-K56 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56).
histone acetyltransferase activity (H3-K9 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9).
peptide-lysine-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.

18 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
histone acetylation The modification of a histone by the addition of an acetyl group.
histone H3 acetylation The modification of histone H3 by the addition of an acetyl group.
histone H3-K14 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.
histone H3-K23 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone.
histone H3-K27 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone.
histone H3-K56 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone.
histone H3-K9 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.
maintenance of rDNA Any process involved in sustaining the fidelity and copy number of rDNA repeats.
negative regulation of transposition, RNA-mediated Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
peptidyl-lysine acetylation The acetylation of peptidyl-lysine.
protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
regulation of double-strand break repair via nonhomologous end joining Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription from RNA polymerase II promoter in response to stress Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
replication-born double-strand break repair via sister chromatid exchange The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLNDFLSSV LPVSEQFEYL SLQSIPLETH AVVTPNKDDK RVPKSTIKTQ HFFSLFHQGK
70 80 90 100 110 120
VFFSLEVYVY VTLWDEADAE RLIFVSKADT NGYCNTRVSV RDITKIILEF ILSIDPNYYL
130 140 150 160 170 180
QKVKPAIRSY KKISPELISA ASTPARTLRI LARRLKQSGS TVLKEIESPR FQQDLYLSFT
190 200 210 220 230 240
CPREILTKIC LFTRPASQYL FPDSSKNSKK HILNGEELMK WWGFILDRLL IECFQNDTQA
250 260 270 280 290 300
KLRIPGEDPA RVRSYLRGMK YPLWQVGDIF TSKENSLAVY NIPLFPDDPK ARFIHQLAEE
310 320 330 340 350 360
DRLLKVSLSS FWIELQERQE FKLSVTSSVM GISGYSLATP SLFPSSADVI VPKSRKQFRA
370 380 390 400 410 420
IKKYITGEEY DTEEGAIEAF TNIRDFLLLR MATNLQSLTG KREHRERNQP VPASNINTLA
430
ITMLKPRKKA KALPKT