Q07471
Gene name |
THI3 (KID1, YDL080C) |
Protein name |
Thiamine metabolism regulatory protein THI3 |
Names |
Keto isocaproate decarboxylase 1, Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase, 2ODC |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL080C |
EC number |
4.1.1.72: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q07471
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07471-F1 | Predicted | AlphaFoldDB |
14 variants for Q07471
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-312468 | 2 | N>D | No | SGRP | |
| s04-312431 | 14 | C>Y | No | SGRP | |
| s04-312363 | 37 | S>P | No | SGRP | |
| s04-312186 | 96 | V>M | No | SGRP | |
| s04-312042 | 144 | A>T | No | SGRP | |
| s04-311840 | 211 | V>A | No | SGRP | |
| s04-311787 | 229 | V>I | No | SGRP | |
| s04-311442 | 344 | I>L | No | SGRP | |
| s04-311405 | 356 | Q>R | No | SGRP | |
| s04-311231 | 414 | N>S | No | SGRP | |
| s04-311129 | 448 | F>S | No | SGRP | |
| s04-310765 | 569 | D>E | No | SGRP | |
| s04-310698 | 592 | N>D | No | SGRP | |
| s04-310662 | 604 | K>E | No | SGRP |
No associated diseases with Q07471
No regional properties for Q07471
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q07471 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.72 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| branched-chain-2-oxoacid decarboxylase activity | Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| thiamine pyrophosphate binding | Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid catabolic process via Ehrlich pathway | The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols. |
| branched-chain amino acid catabolic process | The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. |
| positive regulation of thiamine biosynthetic process | Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSSYTQRYA | LPKCIAISDY | LFHRLNQLNI | HTIFGLSGEF | SMPLLDKLYN | IPNLRWAGNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NELNAAYAAD | GYSRLKGLGC | LITTFGVGEL | SAINGVAGSY | AEHVGILHIV | GMPPTSAQTK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QLLLHHTLGN | GDFTVFHRIA | SDVACYTTLI | IDSELCADEV | DKCIKKAWIE | QRPVYMGMPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NQVNLPIESA | RLNTPLDLQL | HKNDPDVEKE | VISRILSFIY | KSQNPAIIVD | ACTSRQNLIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETKELCNRLK | FPVFVTPMGK | GTVNETDPQF | GGVFTGSISA | PEVREVVDFA | DFIIVIGCML |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEFSTSTFHF | QYKTKNCALL | YSTSVKLKNA | TYPDLSIKLL | LQKILANLDE | SKLSYQPSEQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSMMVPRPYP | AGNVLLRQEW | VWNEISHWFQ | PGDIIITETG | ASAFGVNQTR | FPVNTLGISQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ALWGSVGYTM | GACLGAEFAV | QEINKDKFPA | TKHRVILFMG | DGAFQLTVQE | LSTIVKWGLT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PYIFVMNNQG | YSVDRFLHHR | SDASYYDIQP | WNYLGLLRVF | GCTNYETKKI | ITVGEFRSMI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SDPNFATNDK | IRMIEIMLPP | RDVPQALLDR | WVVEKEQSKQ | VQEENENSSA | VNTPTPEFQP |
| LLKKNQVGY |