Q07192
Gene name |
map2k2 (mek2) |
Protein name |
Dual specificity mitogen-activated protein kinase kinase 2 |
Names |
MAP kinase kinase 2, MAPKK 2, MAPK-ERK kinase 2 |
Species |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826/ MSB8) |
KEGG Pathway |
|
EC number |
|
Protein Class |
RNA POLYMERASE SIGMA FACTOR RPO (PTHR30603) |
Descriptions
The σ factors are the key regulators of bacterial transcription initiation. Through direct read-out of promoter DNA sequence, they recruit the core RNA polymerase to sites of initiation, thereby dictating the RNA polymerase promoter-specificity. The group 1 σ factors, which direct the vast majority of transcription initiation during log phase growth and are essential for viability, are autoregulated by an N-terminal sequence known as σ1.1. The group 1 σ factors, which perform the bulk of transcription during exponential growth, are converted from an autoinhibited state, which cannot interact with promoter DNA, to an active form that recognizes promoter DNA upon binding to core RNAP. Biochemical and genetic studies have established that the N-terminal domain of group 1 σ factors, σ1.1, is required for autoinhibition.
Autoinhibitory domains (AIDs)
Accessory elements
293-315 (Activation loop from InterPro)
Target domain |
149-414 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Min X et al. (2009) "The structure of the MAP2K MEK6 reveals an autoinhibitory dimer", Structure (London, England : 1993), 17, 96-104
- Shevchenko E et al. (2020) "The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations", Computational and structural biotechnology journal, 18, 2687-2698
Autoinhibited structure
Activated structure
1 structures for Q07192
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07192-F1 | Predicted | AlphaFoldDB |
No variants for Q07192
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q07192 | |||||
No associated diseases with Q07192
10 regional properties for Q07192
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA polymerase sigma-70 | 183 - 196 | IPR000943-1 |
| domain | RNA polymerase sigma-70 | 207 - 215 | IPR000943-2 |
| domain | RNA polymerase sigma-70 | 331 - 343 | IPR000943-3 |
| domain | RNA polymerase sigma-70 | 352 - 378 | IPR000943-4 |
| domain | RNA polymerase sigma factor 70, region 1.1 | 32 - 108 | IPR007127 |
| domain | RNA polymerase sigma-70 region 3 | 238 - 313 | IPR007624 |
| domain | RNA polymerase sigma-70 region 2 | 159 - 228 | IPR007627 |
| domain | RNA polymerase sigma-70 region 4 | 327 - 380 | IPR007630 |
| domain | RNA polymerase sigma factor RpoD, C-terminal | 155 - 391 | IPR012760 |
| domain | RNA polymerase sigma-70 like domain | 155 - 380 | IPR014284 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR30603 | RNA POLYMERASE SIGMA FACTOR RPO |
| PANTHER Subfamily | PTHR30603:SF47 | RNA POLYMERASE SIGMA FACTOR SIGF, CHLOROPLASTIC |
| PANTHER Protein Class |
helix-turn-helix transcription factor
Sigma factor |
|
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNEEQQVLQE | QHQEQTQEQT | QEQKETLPPQ | IERRIKKLIS | LGKKKGYITY | EDIDKAFPPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEGFDTNLIE | RIHEELEKHG | INIVENEPEE | EEISASSDEQ | ELEELLEKES | PEIHDSSNVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSIKMYLKEI | GKIPLLTPAQ | ERELARRAQM | GDKKAKEKLI | TSNLRLVVSI | AKRYMGRGLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FQDLIQEGNI | GLLKAVEKFD | WRKGYKFSTY | ATWWIRQAIT | RAIADQARTI | RIPVHMVETI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKLNRLRREY | YQKHGEEPSI | EELAKMMGKP | PEKIKEILEA | AKETISLESP | IGEDEDSSIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DFVADDSIAS | PKKEAMRMLM | REELEKVLKT | LSPREAMVLR | MRYGLLDGKP | KTLEEVGQYF |
| 370 | 380 | 390 | |||
| NVTRERIRQI | EVKALRKLRH | PSRSKYLKSL | LSLMDENEG |