Q06755

PR
Gene name
ispD (yacM, BSU00900)
Protein name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Names
4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU00900
EC number
2.7.7.60: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-232 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q06755

Entry ID Method Resolution Chain Position Source
5DDT X-ray 180 A A/B 1-232 PDB
5DDV X-ray 230 A A 1-232 PDB
5HS2 X-ray 190 A A/B 1-232 PDB
AF-Q06755-F1 Predicted AlphaFoldDB

No variants for Q06755

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06755

No associated diseases with Q06755

1 regional properties for Q06755

Type Name Position InterPro Accession
conserved_site 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site 100 - 107 IPR018294

Functions

Description
EC Number 2.7.7.60 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.

2 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYDVVIPAA GQGKRMKAGR NKLFIELKGD PVIIHTLRVF DSHRQCDKII LVINEQEREH
70 80 90 100 110 120
FQQLLSDYPF QTSIELVAGG DERQHSVYKG LKAVKQEKIV LVHDGARPFI KHEQIDELIA
130 140 150 160 170 180
EAEQTGAAIL AVPVKDTIKR VQDLQVSETI ERSSLWAVQT PQAFRLSLLM KAHAEAERKG
190 200 210 220 230
FLGTDDASLV EQMEGGSVRV VEGSYTNIKL TTPDDLTSAE AIMESESGNK HV