Q06685
PR
Gene name |
VIP1 |
Protein name |
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase |
Names |
InsP6 and PP-IP5 kinase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR410W |
EC number |
2.7.4.24: Phosphotransferases with a phosphate group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06685
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06685-F1 | Predicted | AlphaFoldDB |
12 variants for Q06685
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-937603 | 22 | N>S | No | SGRP | |
| s12-937819 | 94 | A>E | No | SGRP | |
| s12-938062 | 175 | S>F | No | SGRP | |
| s12-938119 | 194 | A>V | No | SGRP | |
| s12-938487 | 317 | H>N | No | SGRP | |
| s12-938659 | 374 | R>H | No | SGRP | |
| s12-938796 | 420 | E>K | No | SGRP | |
| s12-939808 | 757 | E>G | No | SGRP | |
| s12-940191 | 885 | M>L | No | SGRP | |
| s12-940633 | 1032 | T>M | No | SGRP | |
| s12-940924 | 1129 | R>L | No | SGRP | |
| s12-940969 | 1144 | T>R | No | SGRP |
No associated diseases with Q06685
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.4.24 | Phosphotransferases with a phosphate group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
13 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-diphosphoinositol pentakisphosphate 3-kinase activity | Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| diphosphoinositol-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. |
| inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity | Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate. |
| inositol heptakisphosphate kinase activity | Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown. |
| inositol hexakisphosphate 1-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate. |
| inositol hexakisphosphate 3-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. |
| inositol hexakisphosphate 4-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate. |
| inositol hexakisphosphate 5-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| inositol hexakisphosphate 6-kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. |
| inositol hexakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. |
| inositol-1,3,4,5,6-pentakisphosphate kinase activity | Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. |
| inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity | Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| inositol metabolic process | The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
| inositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| regulation of bipolar cell growth | Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of microtubule cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGIKKEPIE | SDEVPQQETK | NNLPSAPSEM | SPLFLNKNTQ | KAMQSIAPIL | EGFSPKTSAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENMSLKLPPP | GIQDDHSEEN | LTVHDTLQRT | ISTALGNGNN | TNTVTTSGLK | KADSESKSEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPEGLSNSNI | VNDADNINSI | SKTGSPHLPQ | GTMDAEQTNM | GTNSVPTSSA | SSRKSSTSHP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPRLPKVGKI | GVCAMDAKVL | SKPMRHILNR | LIEHGEFETV | IFGDKVILDE | RIENWPTCDF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LISFFSSGFP | LDKAIKYVKL | RKPFIINDLI | MQKILWDRRL | CLQVLEAYNV | PTPPRLEISR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DGGPRANEEL | RAKLREHGVE | VKPVEEPEWK | MVDDDTLEVD | GKTMTKPFVE | KPVDGEDHNI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YIYYHSKNGG | GGRRLFRKVG | NKSSEFDPTL | VHPRTEGSYI | YEQFMDTDNF | EDVKAYTIGE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NFCHAETRKS | PVVDGIVRRN | THGKEVRYIT | ELSDEEKTIA | GKVSKAFSQM | ICGFDLLRVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GKSYVIDVNG | FSFVKDNKAY | YDSCANILRS | TFIEAKKKMD | MEKKNLPIIR | EEKEQKWVFK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GLAIIIRHAD | RTPKQKFKHS | FTSPIFISLL | KGHKEEVVIR | NVNDLKIVLQ | ALRIALDEKA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GNPAKIKVLA | NALEKKLNFP | GTKIQLKPVL | NKENEVEKVQ | FILKWGGEPT | HSAKYQATEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GEQMRQDFDL | LNKSILQNIK | IFSSSERRVL | HTAQYWTRAL | FGADELGSDE | ISIRKDLLDD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SNAAKDLMDK | VKKKLKPLLR | EGKEAPPQFA | WPSKMPEPYL | VIKRVVELMN | YHKKIMDNNF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AKKDVNSMQT | RWCTSEDPSL | FKERWDKLFK | EFNNAEKVDP | SKISELYDTM | KYDALHNRQF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LENIFDPGLP | NEAIADELGS | HSLVDRYPIN | VLAKNNFKII | DSHSMNNSGK | NSSNSVGSLG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WVLESGKTST | ARNPKSSSQF | DEPRFMQLRE | LYKLAKVLFD | FICPKEYGIS | DAEKLDIGLL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TSLPLAKQIL | NDIGDMKNRE | TPACVAYFTK | ESHIYTLLNI | IYESGIPMRI | ARNALPELDY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LSQITFELYE | STDASGQKSH | SIRLKMSPGC | HTQDPLDVQL | DDRHYISCIP | KISLTKHLDM |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DYVQQKLRNK | FTRVIMPPKF | TPVNITSPNL | SFQKRKTRRK | SVSVEKLKRP | ASSGSSSSTS |
| VNKTLD |