Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06649
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06649-F1 | Predicted | AlphaFoldDB |
No variants for Q06649
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q06649 | |||||
No associated diseases with Q06649
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P78314 | SH3BP2 | SH3 domain-binding protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAEEMQWPV | PMKAIGAQNL | LTMPGGVAKA | GYLHKKGGTQ | LQLLKWPLRF | VIIHKRCIYY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKSSTSASPQ | GAFSLSGYNR | VMRAAEETTS | NNVFPFKIIH | ISKKHRTWFF | SASSEDERKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WMAFVRREIG | HFHEKKELPL | DTSDSSSDTD | SFYGAVERPI | DISLSSYPMD | NEDYEHEDED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSYLEPDSPG | PMKLEDALTY | PPAYPPPPVP | VPRKPAFSDL | PRAHSFTSKS | PSPLLPPPPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRGLPDTGSA | PEDAKDALGL | RRVEPGLRVP | ATPRRMSDPP | MSNVPTVPNL | RKHPCFRDSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPGLEPWTPG | HGTSSVSSST | TMAVATSRNC | DKLKSFHLSS | RGPPTSEPPP | VPANKPKFLK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IAEEPSPREA | AKFAPVPPVA | PRPPVQKMPM | PEATVRPAVL | PRPENTPLPH | LQRSPPDGQS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FRGFSFEKAR | QPSQADTGEE | DSDEDYEKVP | LPNSVFVNTT | ESCEVERLFK | ATDPRGEPQD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLYCIRNSST | KSGKVLVVWD | ESSNKVRNYR | IFEKDSKFYL | EGEVLFASVG | SMVEHYHTHV |
| 550 | |||||
| LPSHQSLLLR | HPYGYAGPR |