Q06625
PR
Gene name |
GDB1 (YPR184W) |
Protein name |
Glycogen debranching enzyme |
Names |
Glycogen debrancher |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR184W |
EC number |
2.4.1.25: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06625
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06625-F1 | Predicted | AlphaFoldDB |
24 variants for Q06625
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-902159 | 40 | D>E | No | SGRP | |
| s16-902239 | 67 | P>L | No | SGRP | |
| s16-902264 | 75 | K>N | No | SGRP | |
| s16-902925 | 296 | V>I | No | SGRP | |
| s16-903142 | 368 | R>K | No | SGRP | |
| s16-903229 | 397 | Q>R | No | SGRP | |
| s16-903411 | 458 | K>Q | No | SGRP | |
| s16-903688 | 550 | D>G | No | SGRP | |
| s16-903951 | 638 | S>A | No | SGRP | |
| s16-904082 | 681 | E>D | No | SGRP | |
| s16-904224 | 729 | P>S | No | SGRP | |
| s16-904290 | 751 | A>T | No | SGRP | |
| s16-904359 | 774 | D>N | No | SGRP | |
| s16-904485 | 816 | A>S | No | SGRP | |
| s16-904505 | 822 | D>E | No | SGRP | |
| s16-904681 | 881 | S>Y | No | SGRP | |
| s16-905112 | 1025 | A>T | No | SGRP | |
| s16-905578 | 1180 | R>K | No | SGRP | |
| s16-905592 | 1185 | S>P | No | SGRP | |
| s16-905906 | 1289 | K>N | No | SGRP | |
| s16-905961 | 1308 | D>N | No | SGRP | |
| s16-906057 | 1340 | A>P | No | SGRP | |
| s16-906505 | 1489 | F>S | No | SGRP | |
| s16-906650 | 1537 | S>W | No | SGRP |
No associated diseases with Q06625
4 regional properties for Q06625
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Eukaryotic glycogen debranching enzyme, N-terminal domain | 47 - 134 | IPR029436 |
| domain | Glycogen debranching enzyme, central domain | 732 - 975 | IPR032788 |
| domain | Glycogen debranching enzyme, C-terminal | 1045 - 1523 | IPR032790 |
| domain | Glycogen debranching enzyme, glucanotransferase domain | 122 - 592 | IPR032792 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.25 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4-alpha-glucanotransferase activity | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. |
| amylo-alpha-1,6-glucosidase activity | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. |
| beta-maltose 4-alpha-glucanotransferase activity | Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen biosynthetic process | The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| glycogen catabolic process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRSLLLRLS | DTGEPITSCS | YGKGVLTLPP | IPLPKDAPKD | QPLYTVKLLV | SAGSPVARDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVWTNCPPDH | NTPFKRDKFY | KKIIHSSFHE | DDCIDLNVYA | PGSYCFYLSF | RNDNEKLETT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKYYFVALPM | LYINDQFLPL | NSIALQSVVS | KWLGSDWEPI | LSKIAAKNYN | MVHFTPLQER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GESNSPYSIY | DQLQFDQEHF | KSPEDVKNLV | EHIHRDLNML | SLTDIVFNHT | ANNSPWLVEH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PEAGYNHITA | PHLISAIELD | QELLNFSRNL | KSWGYPTELK | NIEDLFKIMD | GIKVHVLGSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLWEYYAVNV | QTALRDIKAH | WNDESNESYS | FPENIKDISS | DFVKLASFVK | DNVTEPNFGT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGERNSNRIN | VPKFIQLLKL | INDGGSDDSE | SSLATAQNIL | NEVNLPLYRE | YDDDVSEILE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLFNRIKYLR | LDDGGPKQGP | VTVDVPLTEP | YFTRFKGKDG | TDYALANNGW | IWNGNPLVDF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASQNSRAYLR | REVIVWGDCV | KLRYGKSPED | SPYLWERMSK | YIEMNAKIFD | GFRIDNCHST |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PIHVGEYFLD | LARKYNPNLY | VVAELFSGSE | TLDCLFVERL | GISSLIREAM | QAWSEEELSR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVHKHGGRPI | GSYKFVPMDD | FSYPADINLN | EEHCFNDSND | NSIRCVSEIM | IPKILTATPP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HALFMDCTHD | NETPFEKRTV | EDTLPNAALV | ALCSSAIGSV | YGYDEIFPHL | LNLVTEKRHY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DISTPTGSPS | IGITKVKATL | NSIRTSIGEK | AYDIEDSEMH | VHHQGQYITF | HRMDVKSGKG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| WYLIARMKFS | DNDDPNETLP | PVVLNQSTCS | LRFSYALERV | GDEIPNDDKF | IKGIPTKLKE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LEGFDISYDD | SKKISTIKLP | NEFPQGSIAI | FETQQNGVDE | SLDHFIRSGA | LKATSSLTLE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SINSVLYRSE | PEEYDVSAGE | GGAYIIPNFG | KPVYCGLQGW | VSVLRKIVFY | NDLAHPLSAN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LRNGHWALDY | TISRLNYYSD | EAGINEVQNW | LRSRFDRVKK | LPSYLVPSYF | ALIIGILYGC |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| CRLKAIQLMS | RNIGKSTLFV | QSLSMTSIQM | VSRMKSTSIL | PGENVPSMAA | GLPHFSVNYM |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RCWGRDVFIS | LRGMLLTTGR | FDEAKAHILA | FAKTLKHGLI | PNLLDAGRNP | RYNARDAAWF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FLQAVQDYVY | IVPDGEKILQ | EQVTRRFPLD | DTYIPVDDPR | AFSYSSTLEE | IIYEILSRHA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KGIKFREANA | GPNLDRVMTD | KGFNVEIHVD | WSTGLIHGGS | QYNCGTWMDK | MGESEKAGSV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GIPGTPRDGA | AIEINGLLKS | ALRFVIELKN | KGLFKFSDVE | TQDGGRIDFT | EWNQLLQDNF |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| EKRYYVPEDP | SQDADYDVSA | KLGVNRRGIY | RDLYKSGKPY | EDYQLRPNFA | IAMTVAPELF |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| VPEHAIKAIT | IADEVLRGPV | GMRTLDPSDY | NYRPYYNNGE | DSDDFATSKG | RNYHQGPEWV |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| WLYGYFLRAF | HHFHFKTSPR | CQNAAKEKPS | SYLYQQLYYR | LKGHRKWIFE | SVWAGLTELT |
| 1510 | 1520 | 1530 | |||
| NKDGEVCNDS | SPTQAWSSAC | LLDLFYDLWD | AYEDDS |