Q06316

PR
Gene name
bla
Protein name
Beta-lactamase
Names
Penicillinase
Species
Amycolatopsis lactamdurans (Nocardia lactamdurans)
KEGG Pathway
EC number
3.5.2.6: In cyclic amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06316

Entry ID Method Resolution Chain Position Source
AF-Q06316-F1 Predicted AlphaFoldDB

No variants for Q06316

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06316

No associated diseases with Q06316

2 regional properties for Q06316

Type Name Position InterPro Accession
active_site Beta-lactamase, class-A active site 81 - 96 IPR023650
domain Beta-lactamase class A, catalytic domain 61 - 276 IPR045155

Functions

Description
EC Number 3.5.2.6 In cyclic amides
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
beta-lactamase activity Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.

2 GO annotations of biological process

Name Definition
beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADRRRVHAW ARARPAAPEP APPTPSAAAP SVAPGPAATP PDPAVEQEFT RLQTQYDARL
70 80 90 100 110 120
GLYAVDTGSG ESVAFRADER FAFASTFKAL AAAAVLDSTT PQQLDQVVRY SKDELLENSP
130 140 150 160 170 180
ITKDHVATGM TLRELCDAAV RFSDNTAGNL LLKHVGGPQG LDAALTAVGD EVTSADRWEP
190 200 210 220 230 240
ELNSAVPGDV RDTSTPRALA HDLRQFVLGD ALAEDDRALL TDWLRRNTTG GTVIRAGVPA
250 260 270 280 290 300
DWVVGDKTGS GYYGGRNDIA VLWPPNRAPI VMAVMTSREE PRAKRADALL ADAARVAVTA
LG