Q06282
Gene name |
glpQ (hpd, HI_0689) |
Protein name |
Glycerophosphodiester phosphodiesterase |
Names |
Glycerophosphoryl diester phosphodiesterase, Immunoglobulin D-binding protein, IgD-binding protein, Surface-exposed lipoprotein D, Protein D |
Species |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
KEGG Pathway |
hin:HI_0689 |
EC number |
3.1.4.46: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q06282
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8CWP | X-ray | 180 A | A | 20-364 | PDB |
| AF-Q06282-F1 | Predicted | AlphaFoldDB |
17 variants for Q06282
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 13 | A>T | strain: NCTC 8468 [UniProt] | No | ||
| 16 | L>V | strain: NCTC 8468 [UniProt] | No | ||
| 25 | N>S | strain: NCTC 8468 [UniProt] | No | ||
| 28 | N>K | strain: 6-7626 [UniProt] | No | ||
| 34 | D>H | strain: NCTC 8468 [UniProt] | No | ||
| 62 | H>Q | strain: Eagan, 3639, 3640, 6-7626, HK695 and Minna [UniProt] | No | ||
| 63 | S>A | strain: Eagan, 3639, 3640, NCTC 8468, 6-7626, HK695 and Minna [UniProt] | No | ||
| 98 | Y>H | strain: Eagan, 3639, 3640, NCTC 8468, 6-7626, HK695 and Minna [UniProt] | No | ||
| 99 | R>H | strain: NCTC 8468 [UniProt] | No | ||
| 144 | K>Q | strain: 6-7626 [UniProt] | No | ||
| 168 | K>R | strain: 6-7626 [UniProt] | No | ||
| 191 | T>A | strain: Eagan, 3639, 3640, NCTC 8468, 6-7626, HK695 and Minna [UniProt] | No | ||
| 253 | P>S | strain: 6-7626 [UniProt] | No | ||
| 310 | Q>K | strain: 6-7626 [UniProt] | No | ||
| 327 | E>A | strain: Eagan, 3639, NCTC 8468, 6-7626, HK695 and Minna [UniProt] | No | ||
| 338 | A>V | strain: Eagan, 3640, HK695 and Minna [UniProt] | No | ||
| 364 | K>E | strain: 6-7626 [UniProt] | No |
No associated diseases with Q06282
1 regional properties for Q06282
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycerophosphodiester phosphodiesterase domain | 35 - 360 | IPR030395 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.46 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell outer membrane | A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. |
| periplasmic space | The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycerophosphodiester phosphodiesterase activity | Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycerol metabolic process | The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLKTLALSL | LAAGVLAGCS | SHSSNMANTQ | MKSDKIIIAH | RGASGYLPEH | TLESKALAFA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QHSDYLEQDL | AMTKDGRLVV | IHDHFLDGLT | DVAKKFPYRH | RKDGRYYVID | FTLKEIQSLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MTENFETKDG | KQAQVYPNRF | PLWKSHFRIH | TFEDEIEFIQ | GLEKSTGKKV | GIYPEIKAPW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FHHQNGKDIA | TETLKVLKKY | GYDKKTDMVY | LQTFDFNELK | RIKTELLPQM | GMDLKLVQLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AYTDWKETQE | KDPKGYWVNY | NYDWMFKPGA | MAEVVKYADG | VGPGWYMLVN | KEESKPDNIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YTPLVKELAQ | YNVEVHPYTV | RKDALPEFFT | DVNQMYDALL | NKSGATGVFT | DFPDTGVEFL |
| KGIK |