Q06217

PR
Gene name
SMD2 (YLR275W, L9328.5)
Protein name
Small nuclear ribonucleoprotein Sm D2
Names
Sm-D2, snRNP core protein D2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR275W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

33 structures for Q06217

Entry ID Method Resolution Chain Position Source
3JCM EM 380 A Q/U 1-110 PDB
5GAM EM 370 A j 1-110 PDB
5GAN EM 360 A j/m 1-110 PDB
5GAO EM 360 A m 1-110 PDB
5GM6 EM 350 A g 15-108 PDB
5GMK EM 340 A e/g 1-110 PDB
5LJ3 EM 380 A j/m 1-110 PDB
5LJ5 EM 380 A j/m 1-110 PDB
5LQW EM 580 A j 1-110 PDB
5MPS EM 385 A j 1-110 PDB
5MQ0 EM 417 A j/m 1-110 PDB
5NRL EM 720 A i/m/u 1-110 PDB
5WSG EM 400 A W/g 1-110 PDB
5Y88 EM 370 A g/n 1-110 PDB
5YLZ EM 360 A g/n 1-110 PDB
5ZWM EM 340 A R/c/n 1-110 PDB
5ZWN EM 330 A c 1-110 PDB
5ZWO EM 390 A R/c/n 1-110 PDB
6BK8 EM 330 A a/q 1-110 PDB
6EXN EM 370 A j/m 1-110 PDB
6G90 EM 400 A i/u 1-110 PDB
6J6G EM 320 A e/g 1-110 PDB
6J6H EM 360 A e/g 1-110 PDB
6J6N EM 386 A e/g 1-110 PDB
6J6Q EM 370 A e/g 1-110 PDB
6N7P EM 360 A M 1-110 PDB
6N7R EM 320 A M 1-110 PDB
6N7X EM 360 A M 1-110 PDB
7B9V EM 280 A j/m 1-110 PDB
7OQB EM 900 A u 1-110 PDB
7OQC EM 410 A i 1-110 PDB
7OQE EM 590 A i/u 1-110 PDB
AF-Q06217-F1 Predicted AlphaFoldDB

No variants for Q06217

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06217

No associated diseases with Q06217

2 regional properties for Q06217

Type Name Position InterPro Accession
domain Sm domain, eukaryotic/archaea-type 32 - 106 IPR001163
domain Sm domain 31 - 110 IPR047575

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
commitment complex A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
U1 snRNP A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes.
U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
U4 snRNP A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.
U4/U6 snRNP A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes.
U4/U6 x U5 tri-snRNP complex A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs.
U5 snRNP A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
7-methylguanosine cap hypermethylation Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.
mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling spliceosome.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
spliceosomal snRNP assembly The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
U2-type prespliceosome assembly The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSQIIDRPK HELSRAELEE LEEFEFKHGP MSLINDAMVT RTPVIISLRN NHKIIARVKA
70 80 90 100
FDRHCNMVLE NVKELWTEKK GKNVINRERF ISKLFLRGDS VIVVLKTPVE