Q06128

PR
Gene name
trpE (SSO0893)
Protein name
Anthranilate synthase component 1
Names
AS, ASI
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO0893
EC number
4.1.3.27: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

211-290 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q06128

Entry ID Method Resolution Chain Position Source
1QDL X-ray 250 A A 1-421 PDB
AF-Q06128-F1 Predicted AlphaFoldDB

No variants for Q06128

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06128

No associated diseases with Q06128

2 regional properties for Q06128

Type Name Position InterPro Accession
domain Anthranilate synthase component I, N-terminal 11 - 130 IPR006805
domain Chorismate-utilising enzyme, C-terminal 157 - 410 IPR015890

Functions

Description
EC Number 4.1.3.27 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVHPISEFA SPFEVFKCIE RDFKVAGLLE SIGGPQYKAR YSVIAWSTNG YLKIHDDPVN
70 80 90 100 110 120
ILNGYLKDLK LADIPGLFKG GMIGYISYDA VRFWEKIRDL KPAAEDWPYA EFFTPDNIII
130 140 150 160 170 180
YDHNEGKVYV NADLSSVGGC GDIGEFKVSF YDESLNKNSY ERIVSESLEY IRSGYIFQVV
190 200 210 220 230 240
LSRFYRYIFS GDPLRIYYNL RRINPSPYMF YLKFDEKYLI GSSPELLFRV QDNIVETYPI
250 260 270 280 290 300
AGTRPRGADQ EEDLKLELEL MNSEKDKAEH LMLVDLARND LGKVCVPGTV KVPELMYVEK
310 320 330 340 350 360
YSHVQHIVSK VIGTLKKKYN ALNVLSATFP AGTVSGAPKP MAMNIIETLE EYKRGPYAGA
370 380 390 400 410 420
VGFISADGNA EFAIAIRTAF LNKELLRIHA GAGIVYDSNP ESEYFETEHK LKALKTAIGV
R