Q06034
Gene name |
MDR1 |
Protein name |
Multidrug resistance protein 1 |
Names |
P-glycoprotein 1 |
Species |
Leishmania enriettii |
KEGG Pathway |
|
EC number |
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06034
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06034-F1 | Predicted | AlphaFoldDB |
1 variants for Q06034
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 286 | G>D | No |
No associated diseases with Q06034
No regional properties for Q06034
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q06034 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 7.6.2.2 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type xenobiotic transporter activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| response to antibiotic | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRAHAAYAN | EGWSAPEGGI | AGKDGSTRDC | SGYGSQGPLF | SAEEEVKGTV | VRETVGPIEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FRYADATDRV | LMIAGTAFAV | ACGAGMPVFS | FIFGRIAMDL | MSGVGSAEEK | AAKTSLIMVY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGIAMLIACA | GHVMCWTVAA | CRQVARIRLL | FFRAVLRQDI | GWHDEHSPGA | LTARMTGDTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIQNGINDKL | SQGIMNGSMG | VIGYIAGFVF | SWELTLMMIG | MMPFIIVMAA | IIGSIVSKIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESSRKYFAKA | GSLATEVMEN | IRTVQAFGRE | DYELERFTKA | VLYAQGRGIR | KELASNLSAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIMALMYVSY | TVAFFFGSYL | VEWGRRDMAD | IISTFLAVLM | GSFGLGFVAP | SRTAFTESRA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAYEIFKAID | RVPPVDIDAG | GVPVPGFKES | IEFRNVRFAY | PTRPGMILFR | DLSLKIKCGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVAFSGASGC | GKSSVIGLIQ | RFYDPIGGAV | LVDGVRMREL | CLREWRDQIG | IVSQEPNLFA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GTMMENVRMG | KPNATDEEVV | EACRQANIHD | TIMALPDRYD | TPVGPVGSLL | SGGQKQRIAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ARALVKRPPI | LLLDEATSAL | DRKSEMEVQA | ALDQLIQRGG | TTVVVIAHRL | ATIRDMDRIY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YVKHDGAEGS | RITESGTFDE | LLELDGEFAA | VAKMQGVLAG | DAKSGASVRD | AKKASGHLGV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ILDEADLAQL | DEDVPRTARQ | NVPIDELAKW | EVKHAKVGFL | RLMRMNKDKA | WAVALGILSS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVIGSARPAS | SIVMGHMLRV | LGEYSATKDV | EALRSGTNLY | APLFIVFAVA | NFSGWILHGF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YGYAGEHLTT | KIRVLLFRQI | MRQDINFFDI | PGRDAGTLAG | MLSGDCEAVH | QLWGPSIGLK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VQTMCIIASG | LVVGFIYQWK | LALVALACMP | LMIGCSLTRR | LMINGYTKSR | EGDTDDTIVT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EALSNVRTVT | SLNMKEDCVE | AFQAALREEA | PRSVRKGIIA | GGIYGITQFI | FYGVYALCFW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YGSKLIDKGE | AEFKDVMIAS | MSILFGAQNA | GEAGAFATKL | ADAEASAKRV | FSVIDRVPDV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DIEQAGNKDL | GEGCDIEYRN | VQFIYSARPK | QVVLASVNMR | FGDATSNGLI | GQTGCGKSTV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| IQMLARFYER | RSGLISVNGR | DLSSLDIAEW | RRNISIVLQE | PNLFSGTVRE | NIRYAREGAT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| DEEVEEAARL | AHIHHEIIKW | TDGYDTEVGY | KGRALSGGQK | QRIAIARGLL | RRPRLLLLDE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ATSALDSVTE | AKVQEGIEAF | QAKYKVTTVS | IAHRLTTIRH | CDQIILLDSG | CIIEQGSHEE |
| 1270 | |||||
| LMALGGEYKT | RYDLYMSALS |