Q06031

PR
Gene name
gp63
Protein name
Leishmanolysin homolog
Names
Cell surface protease, Major surface glycoprotein, Protein gp63
Species
Crithidia fasciculata
KEGG Pathway
EC number
3.4.24.36: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06031

Entry ID Method Resolution Chain Position Source
AF-Q06031-F1 Predicted AlphaFoldDB

No variants for Q06031

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q06031

No associated diseases with Q06031

No regional properties for Q06031

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q06031

Functions

Description
EC Number 3.4.24.36 Metalloendopeptidases
Subcellular Localization
  • Cell membrane ; Lipid-anchor, GPI-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

2 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHAPPTATRR SGPRRTHGIM ARLVRLAAGV LVVTLVIGAL TALSADDAKT HPHKVCIHDE
70 80 90 100 110 120
LQQSLLDSVA QQGLAPQRVS RVGLPYVASA TAAPAAQVGG VDFALAGDSA PDVTRSAEWG
130 140 150 160 170 180
ELRITVSAEE LTDPAYHCAT VGQVISNHID DYVTCTADDI MTAEKLDILM NYLIPEALQM
190 200 210 220 230 240
HKDRLQVQQV QGTWKVARMT SYCGRFKVPE EHFTTGLSNT DFVLYVASVP TSPGVLAWAN
250 260 270 280 290 300
TCQVFSNDQP AVGVINIPAA TITERYDHLM VHAVTHEIAH SLGFSNAFFT NTGIGQFVTG
310 320 330 340 350 360
VRGNPDTVPV INSPTVVAKA REHYGCDDVT YVELEDAGGS GTMGSHWKIR NAQDELMAGI
370 380 390 400 410 420
SGVAYYTSLT LSAFEDLGYY KANYSNAETM KWGKDVGCAF LTGKCVVDNV TQFPSMYCDK
430 440 450 460 470 480
DENVYRCHTA RLNLGSCEVT DYTFDLPDYL QYFTVPSVGG SADYYDYCPY IVRSPIGSCT
490 500 510 520 530 540
QAASSASPFV SAFNTFSMAS RCIDGTFTPK STGGATVTAH LGMCTNVACN TADKTYSIQV
550 560 570 580 590 600
YGNGAYIPCT PGATISLDTV SDAFEAGGNI TCPPYLEVCQ SNVKGAMDYE SMTNSGSGSS
610 620 630 640 650
RPAPVEPSGS GSGSSAATTA PSPTRDGSAA ADRIAPRTAA VALLALAVAA ACV