Q059Y8
Gene name |
Dcst1 |
Protein name |
E3 ubiquitin-protein ligase DCST1 |
Names |
DC-STAMP domain-containing protein 1, RING-type E3 ubiquitin transferase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77772 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q059Y8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q059Y8-F1 | Predicted | AlphaFoldDB |
40 variants for Q059Y8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388631479 | 19 | R>W | No | EVA | |
| rs3388634788 | 26 | N>I | No | EVA | |
| rs3388646717 | 29 | L>Q | No | EVA | |
| rs3388642673 | 39 | R>L | No | EVA | |
| rs3393437040 | 44 | K>I | No | EVA | |
| rs3388634757 | 46 | P>S | No | EVA | |
| rs3388629476 | 100 | M>T | No | EVA | |
| rs3388646688 | 232 | D>N | No | EVA | |
| rs3388644620 | 239 | D>V | No | EVA | |
| rs221360714 | 264 | V>M | No | EVA | |
| rs243081603 | 274 | I>T | No | EVA | |
| rs235886865 | 275 | H>Q | No | EVA | |
| rs3388643331 | 293 | K>I | No | EVA | |
| rs3388631439 | 298 | R>C | No | EVA | |
| rs214157329 | 298 | R>H | No | EVA | |
| rs257378576 | 324 | I>M | No | EVA | |
| rs3388638300 | 351 | G>* | No | EVA | |
| rs3388641786 | 397 | Q>K | No | EVA | |
| rs3388642740 | 421 | Y>C | No | EVA | |
| rs3393367579 | 460 | K>E | No | EVA | |
| rs3388638304 | 467 | I>F | No | EVA | |
| rs3388646672 | 488 | E>V | No | EVA | |
| rs3388644654 | 497 | L>M | No | EVA | |
| rs3388637249 | 498 | V>L | No | EVA | |
| rs3388631475 | 504 | W>C | No | EVA | |
| rs3388639244 | 511 | D>V | No | EVA | |
| rs3388634732 | 517 | S>Y | No | EVA | |
| rs3388639279 | 529 | L>M | No | EVA | |
| rs3388624607 | 535 | G>R | No | EVA | |
| rs3388634801 | 563 | M>K | No | EVA | |
| rs3388637258 | 568 | Q>K | No | EVA | |
| rs3388637321 | 570 | I>F | No | EVA | |
| rs238610135 | 571 | S>G | No | EVA | |
| rs221014351 | 579 | K>R | No | EVA | |
| rs3388629487 | 611 | K>N | No | EVA | |
| rs3388639228 | 620 | F>S | No | EVA | |
| rs3388642736 | 644 | N>D | No | EVA | |
| rs3388643262 | 645 | Q>* | No | EVA | |
| rs3388644651 | 699 | C>S | No | EVA | |
| rs219612280 | 706 | L>H | No | EVA |
No associated diseases with Q059Y8
1 regional properties for Q059Y8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dendritic cell-specific transmembrane protein-like | 431 - 621 | IPR012858 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| negative regulation of type I interferon-mediated signaling pathway | Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5T1A1 | DCST2 | DC-STAMP domain-containing protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFLSSTLHS | LGIFEKISRI | KEVLKNRLLD | LTKRRDQARE | QQRKRPHTII | QGLLLWSLPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SWIRFLWRQP | GEFPVTAFLL | GAGTGGLLAI | GLFQLLVNPM | NIYEEQKVVA | LYCLASLGAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GWGTSPHIRC | ASLLLVPKML | GKEGRLFVMG | YALAAIYSGP | AANLRSNINE | VIASLGCTVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQINNTRSAW | RVSTAPLRAV | FKGMVGSKDS | LNKEIQNVST | SFEEMDEQVK | SDAGYSSEDW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKNRESTEMF | GTSRVRPYLS | TQMVYELRTR | LRCIHVVNKA | ILSCYRWFDK | KHKNCMRRIH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPLFNNMICV | PMKFKFLCNI | AKVIEIWCYK | RIPVEGNFGQ | TYDSVNQSIH | GLSGEFSANI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLKEEKQSSM | VGLNTTNWEH | MGTEVRDYVR | QQETYLQWAM | GLLHVLLSCT | FLLVFHSAFS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YMDHYNWDIR | FDNIYISTYF | CQIDARRKKL | GKQSLLPLRK | AERKTVIFPF | KATIQAWEMR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YVIRELLETL | PIVLLLLVLC | AIDWALYSVF | DTIRQHSFVQ | YSFRSSHKLE | IKVEGDSILA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLLRKTIGAL | NTSSSTDVET | NNMPCLPQPI | SLNARDYFKA | SLPTLLLVCL | CLAQAFGYRL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RRVIAAFYFP | KREKKRALFF | YNEFLKKRSA | FTKLRRAAIV | RRANQQKAPP | HYLVEALYRR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| CPLLHRFMRQ | RCVVCQAMET | PDSYVCPTPD | CKALYCRSCW | DDMQRLCPVC | TPREELSSSA |
| 730 | |||||
| HSDSNDDAVY | GD |